Emerging Trends in Moyamoya Disease: Diagnostic and Therapeutic Innovations

Moyamoya disease is a progressive cerebrovascular disorder marked by the narrowing and eventual occlusion of the terminal internal carotid arteries, leading to the development of a network of abnormal tiny vessels at the base of skull that attempt to compensate for reduced blood flow. The current literature underscores the urgency in improving diagnostic methods and treatments to better manage this debilitating condition. Innovations in imaging and biomarker development have opened new avenues for early diagnosis and monitoring, yet challenges persist in predicting disease progression and outcomes. Significant work also continues to expand the understanding of the molecular and cellular mechanisms underlying Moyamoya disease, indicating a critical need for comprehensive studies that connect molecular discoveries to clinical practices.

This Research Topic aims to encapsulate and advance the scientific community's ever-expanding knowledge of Moyamoya disease by focusing on innovative diagnostic tools, novel therapeutic strategies, and deeper mechanistic insights. The objective is to not only shed light on recent scientific breakthroughs but also to stimulate development of interventions that can significantly enhance patient outcomes.

In exploring the interplay between advanced imaging techniques and novel therapeutic approaches, this issue sets out to define the scope and limits of current research while pushing the boundaries of what can be achieved in both theory and practice. To gather further insights into this complex disease, we welcome articles addressing, but not limited to, the following themes:

• Innovative diagnostic tools and biomarkers
• State-of-the-art imaging technologies and their application in Moyamoya disease
• Disease modeling and in vitro/in vivo simulation approaches
• Molecular mechanisms and sequencing techniques
• Clinical trials and outcome analysis

By focusing on these areas, the special issue aims to foster an environment of academic and clinical growth that will eventually translate into improved diagnostics, therapeutics, and overall patient management in Moyamoya disease.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Clinical Trial
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review

Keywords: moyamoya disease, cerebrovascular disorder, diagnosis, treatments, biomarker

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.