Exploring the Biomedical Potential of Nanozymes and Immobilized Enzymes on Nanostructured Materials

Nanobiotechnology has significantly advanced, leading to the development of nanostructured materials that have broadened biomedical applications of biocatalysts. These advancements have not only increased enzyme stability through conformational stiffening but have also preserved their activity within cellular microenvironments. Recent developments have introduced redox-active nanomaterials, known as nanozymes, which mimic natural biocatalysts. These nanozymes provide several advantages over traditional protein-based enzymes, including improved catalytic stability, ease of modification, and lower production costs. Additionally, they inherit the unique properties of nanomaterials, transforming them into versatile platforms that effectively interface with complex biological environments.

This Research Topic aims to provide an overview of the latest advancements in the design, development, and biomedical applications of nanostructured supported biocatalysts and nanozymes. Specifically, it seeks to highlight the transformative impact of merging protein-based enzymes with nanostructured materials to enhance stability, activity, and biocompatibility. The topic also explores how nanozymes present innovative solutions to biomedical challenges, emphasizing their dual functionality, which marries precise catalytic performance with the added benefits of nanomaterials like targeted delivery and multimodal imaging.

To foster groundbreaking research and encourage multidisciplinary collaborations in therapeutic and diagnostic fields, this Research Topic welcomes submissions such as Original Research Articles, Reviews, Mini-Reviews, Systematic Reviews, Perspectives, Commentaries, and Data Reports. Pertinent themes include but are not limited to:

- Development and characterization of enzyme-loaded nanomaterials for improved stability and activity in physiological conditions.
- Tuning the redox properties of artificial nanozymes to meet biomedical needs.
- Immobilized enzymes in targeted drug delivery, oxidative stress mitigation, and enzyme replacement therapies.
- Applications in multimodal imaging, biosensing, and biomarker detection.
- Design of multifunctional theragnostic nanoplatforms.
- Engineering and surface functionalization of nanocarriers for enhanced enzyme immobilization and targeted action.
- Exploration of enzyme-mimetic nanomaterials in specific disease contexts such as neurodegenerative disorders, cancer, and infections.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Nanozymes; Immobilized Enzymes; Nanostructured Biocatalysts; Biomedical Applications; Theragnostic Nanoplatforms

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.