Cardiovascular diseases (CVDs) are the key factors leading to death and disability worldwide. This severe challenge has prompted the scientific research and medical field to constantly seek innovative therapies beyond traditional drug treatment and surgery, especially strategies in tissue engineering. Following this trend, this research topic focuses on myocardial regeneration, cardiac function reconstruction, and the development of advanced design and comprehensive treatment strategies of anticoagulant coated vascular stents. Relying on the latest technological progress, including advanced tissue engineering scaffolds, multifunctional stem cell carriers, intelligent drug delivery systems, and vascular stent coatings with long-term anticoagulation, it has shown significant potential in improving patient prognosis and reducing the burden of cardiovascular disease. It delves into the in-depth discussion and innovative development of biomaterial-based strategies, addressing critical challenges in the treatment of cardiovascular diseases. In addition, we have also considered the potential wide impact of these biomaterials in the treatment of systemic diseases, and are committed to bringing disruptive progress to the diagnosis and treatment of cardiovascular diseases. The topic welcomes, but is not limited to e.g., Original Research, Reviews, Mini Reviews, and short communications.
1. Biomaterials therapy for myocardial infarction and heart failure (1) To develop tissue engineering scaffolds with excellent biocompatibility and biodegradability, aiming to provide a biomimetic environment for cardiomyocytes and promote myocardial regeneration in the infarcted area. (2) To design multifunctional stem cell carriers to enhance the homing, colonization, and differentiation of stem cells in damaged myocardium through precise cell therapy strategies, thereby restoring cardiac function. (3) To research intelligent drug delivery systems to achieve the controlled release of growth factors and anti-inflammatory drugs, reducing myocardial injury and promoting tissue repair.
2. Innovative research and development of anticoagulant-coated vascular stents (1) Exploring new biomaterials for surface modification of vascular stents to achieve a long-term anticoagulant effect and reduce the risk of thrombosis. (2) Studying the dynamic surface chemistry and topological structure of the stent coating to optimize the interaction between blood and the stent surface, thereby reducing inflammatory responses and neointimal hyperplasia.
(3) Evaluating the biocompatibility and mechanical properties of the anticoagulant coating to ensure the long-term stability and functionality of the stent in vivo.
3. The effects of biomaterials on other diseases in the treatment of cardiovascular diseases (1) Analyze how biomaterials used in the treatment of cardiovascular diseases influence systemic inflammatory responses, immune system function, and metabolic processes. (2) Explore interdisciplinary issues that biomaterials may pose in the treatment of cardiovascular diseases, such as the relationship between material-induced chronic inflammation and metabolic diseases like diabetes and obesity. (3) Study how to optimize the design of biomaterials to minimize adverse effects on other disease conditions, such as eye diseases, and achieve therapeutic outcomes for multiple diseases.
Through this research topic, we aim to advance the frontiers of biomaterials science, provide more effective and safer treatment options for cardiovascular diseases, and explore the potential roles of these materials in enhancing the treatment of systemic diseases.
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Article types
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