Integrating innovative biomaterials and molecular biology for bone repair and regeneration

The field of bone repair and regeneration is a critical subset of medical science dealing with the increasing prevalence of bone-related injuries and diseases, largely due to the global population's aging trend. The integration of material science and molecular biology has allowed for substantial improvements in both the functional and structural restoration of bone. Despite these advancements, challenges persist, including the need for materials that can provide adequate mechanical support while promoting cells' proliferative and functional capacities, and the precise manipulation of molecular pathways optimal for bone regeneration. Additionally, cutting-edge technologies like multi-omics, big data analysis, and gene editing technologies continue to evolve and facilitate biomaterials to personalize more effective treatment strategies for bone repair and regeneration.

This Research Topic aims to bridge the knowledge gaps between material innovations and molecular techniques necessary for efficient bone repair and regeneration. The goal is to understand better the interactions between biomaterials and biological processes and how innovative materials can be designed to promote better integration and functionality. Emphasis will also be placed on the utilization of cutting-edge technologies to manipulate growth factors and gene expression to boost the efficacy of bone regeneration interventions, thereby refining these approaches for better outcomes.

To gather further insights into the intricate dynamics of bone repair and regeneration based on biomaterials and molecular strategies, we welcome articles addressing, but not limited to, the following themes:
o The design principles of bone repair materials with the function of enhancing histocompatibility and integration.
o Innovations and technological challenges in developing biomaterials, focusing on bone biomimetic materials, whether functional or structural, such as extracellular matrix-like structural materials and materials combining with promoting bone repair functional factors in bone microenvironment.
o Advanced application of multi-omics and downstream data analysis to identify the pivotal roles of growth factors and signaling molecules in bone repair and regeneration.
o Advanced applications of gene editing technologies (e.g., CRISPR-Cas, phage display technology) in bone regeneration
o Personalized approaches in bone repair through the integration of big data analytics and patient-specific biomaterial designs.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Functional biomaterials, osseointegration, biocompatibility, biological effect, molecular mechanism

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.