Fabrication and integration of micro-biosensors in microfluidic platforms

The field of microfluidics is rapidly evolving, advancing the capabilities and applications of lab-on-chip (LOC) and organ-on-a-chip (OoC) technologies. Benefiting from continuous advancements in microfabrication technologies and materials, the integration of (micro)sensors and (micro)actuators is significantly transforming multiple research areas, including biotechnology, pharmacology, and environmental and biomedical engineering. Microfluidic systems streamline sample preparation, reduce processing time, and minimize reagent use. When combined with biosensor technologies, these systems allow for cost-effective, accurate, and real-time monitoring of environmental conditions and physiological analytes, facilitating enhanced diagnostics and therapeutic applications. Despite these advancements, there are existing challenges, such as limitations in fabrication resolution, material compatibility, signal interference, integration complexity, environmental stability, and cost scalability that need further exploration.



This Research Topic aims to address the ongoing challenges and explore significant advances in integrating (micro)transducers within microfluidic systems for advanced LOC and OoC applications. The goal is to overcome fabrication resolution limits, enhance material compatibility, minimize electronic signal interferences, simplify integration processes, and ensure environmental stability while maintaining cost-effective production. By investigating these critical areas, this Research Topic seeks to facilitate advancements in point-of-care diagnosis and personalized medicine, contributing to the development of next-generation microfluidic devices.



To gather further insights in improving microfluidic integrations, we welcome articles addressing, but not limited to, the following themes:

o Innovations in microfabrication techniques

o Material compatibility and novel (bio)materials for microfluidics

o Solutions for minimizing signal interference in transducers

o Methods for efficient integration and connectivity of components

o Enhancements in environmental stability of integrated systems

o Cost-effective strategies for scalable device production



We encourage the submission of articles, reviews, and experimental studies focusing on both numerical and experimental perspectives in these areas. All submissions will undergo objective and rigorous peer-review to ensure high-quality contributions. Through this Research Topic, we hope to engage the science and engineering community and provide an opportunity to exchange knowledge in the microfabrication, MEMS and micro/nanofluidics fields.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• Mini Review
• Opinion
• Original Research
• Perspective
• Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Editorial
• FAIR² Data
• Mini Review
• Opinion
• Original Research
• Perspective
• Review

Keywords: Biosensors, Integration, Lab-on-a-chip, Microfabrication, Microfluidics, Microsensors, Simulation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.