Intestinal inflammation and its impact on the enteric nervous system

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 31 July 2025 | Manuscript Submission Deadline 18 November 2025

  2. This Research Topic is still accepting articles.

Background

Theme and scope of the collection:



The gastrointestinal tract is a highly dynamic and complex environment regulated by the enteric nervous system (ENS), which coordinates motility, secretion, blood flow, and immune responses. Chronic inflammatory, immune-mediated metabolic disorders, and infection may lead to enteric neuropathy and gastrointestinal dysfunction. Inflammation is a central pathological feature of conditions such as inflammatory bowel disease (IBD), obesity, and type 2 diabetes (T2D). Unlike IBD, obesity and T2D are characterized by chronic low-grade systemic and intestinal inflammation, frequently triggered by long-term consumption of high-fat diets.



This Research Topic mainly focuses on IBD, obesity, and T2D, given their increasing global prevalence, significant clinical and socioeconomic burden, and well-documented effects on gastrointestinal function. Despite their distinct etiologies, these conditions share key pathogenic mechanisms, including disruption of epithelial barrier integrity, persistent activation of the mucosal immune system, gut dysbiosis, and disturbances in the neuroimmune-gut axis.



Emerging evidence indicates that alterations in enteric glial and/or neuronal density, along with changes in their neurochemical and electrical properties and in neuron-glial bidirectional communication, contribute to the etiopathogenesis of characteristic gastrointestinal symptoms such as dysmotility, bloating, visceral hypersensitivity and altered intestinal transit. By highlighting the complex interplay between gut inflammation and the ENS, this research topic aims to identify novel pathophysiological mechanisms and uncover potential therapeutic targets for the management of enteric neuropathies associated with intestinal inflammatory conditions, ranging from immune-mediated diseases to subclinical or low-grade inflammation.



We welcome the submission of Original Research, Brief Research Reports, minireviews and Review Articles focusing on cellular, molecular and functional studies involving animal models, primary cultures, cell lines or intestinal organoids aimed at uncovering the mechanisms underlaying the ENS dysfunctions under inflammatory conditions. We highly appreciate original research studies conducted with human tissue and Clinical Trials or Case Reports that provide translational insight into this field. While the main focus is on IBD, obesity, and T2D, we also encourage submission addressing other inflammatory, metabolic, or immune-mediated disorders that affect the ENS.





Potential themes may include, but are not limited to:



1. Animal models of IBD, obesity, T2D or other intestinal inflammatory diseases investigating ENS involvement.



2. Animal or human studies investigating the effects of gut inflammation on the structure and remodeling of the ENS, including both the myenteric and submucosal plexuses.



3. Reactive glia, enteric gliosis and altered communication within the tripartite synapsis.



4. Impact of intestinal inflammation on neurotransmitter release, neuronal excitability, and synaptic function in the ENS.



5. Gastrointestinal dysfunction—including altered motility, secretion, and sensory perception—associated with ENS alterations in the context of inflammatory conditions



6. Transcriptomic or proteomic studies characterizing inflammation-induced molecular changes in the ENS.



7. Oxidative stress and mitochondrial damage mechanisms triggered by inflammation in enteric neurons and glia.



8. Identification of biomarkers of ENS dysfunction in IBD and other conditions



9. Development of therapeutic strategies targeting the ENS for the treatment of gastrointestinal dysfunction associated with inflammatory conditions.



10. Effects of inflammation-driven gut dysbiosis on ENS structure and function.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Community Case Study
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: "Enteric nervous system"; "Intestinal inflammation"; IBD, obesity; "Type 2 diabetes"; T2D

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