Peripheral nerve disorders—ranging from traumatic nerve transections to chronic nerve entrapment syndromes—pose a major clinical and scientific challenge, often leading to persistent functional impairments, chronic pain, and reduced quality of life. Despite decades of surgical experience and research, full functional recovery remains elusive in many cases, particularly in large-gap injuries, delayed interventions, or cases involving nerve compression and fibrosis.
This Research Topic aims to highlight state-of-the-art strategies for peripheral nerve reconstruction and repair, integrating both experimental and clinical perspectives. The collection brings together original research, clinical reports, and reviews that reflect the growing complexity and interdisciplinarity of this field.
Clinically, significant advances have been made in microsurgical techniques, nerve decompression procedures, and reconstructive strategies involving autografts, processed allografts, and synthetic conduits. Innovations such as ultrasound-guided neurolysis, nerve transfers, and biomaterial-assisted reconstructions are expanding therapeutic options.
This Research Topic welcomes contributions on topics including: • Clinical studies on peripheral nerve repair, reconstruction, and decompression procedures • Surgical outcomes and innovations in the treatment of nerve entrapment syndromes • Pre-clinical models mimicking complex nerve injury scenarios (e.g., chronic, delayed, or large-gap lesions) • Biomaterials and bioengineering approaches for nerve guidance, regeneration, and neuroprotection • Translational strategies bridging the gap between experimental success and clinical implementation
By integrating clinical insights with cutting-edge laboratory discoveries, this Research Topic aims to foster collaboration among neurosurgeons, orthopedic and plastic surgeons, neuroscientists, and biomedical engineers. Our ultimate goal is to advance the understanding and treatment of peripheral nerve pathologies and to accelerate the translation of emerging technologies into effective clinical practice.
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Case Report
Clinical Trial
Curriculum, Instruction, and Pedagogy
Editorial
FAIR² Data
General Commentary
Hypothesis and Theory
Methods
Mini Review
Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.
Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
