Advancing Mental Health Research and Care Using Real World Data

  • 164

    Total views and downloads

About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 22 September 2025 | Manuscript Submission Deadline 10 January 2026

  2. This Research Topic is still accepting articles.

Background

Mental health disorders are a leading cause of global disability, yet significant gaps remain in understanding the real-world effectiveness of treatments, alone or combined, such as pharmacotherapy, pharmacogenomic testing, psychotherapy (e.g., cognitive behavioral therapy), and community-level support. Traditional clinical trials, while essential, often operate under controlled conditions that may not fully capture the complexities of everyday clinical practice and patient navigation in the pursuit of care or support. Real-world data (RWD), including electronic health records, insurance claims, consumer data, local public survey data, and patient registries, offer an opportunity to study treatment effectiveness amid these complexities. Advances in data analytics and large language models have further enhanced the ability to harness RWD for robust, large-scale analyses. This special research topic aims to explore innovative applications of RWD assessment to evaluate treatment effectiveness, optimize care delivery, and inform evidence-based decision-making, ultimately improving mental health services research and patient outcomes.

Despite the growing availability of RWD, its potential to generate real-world evidence (RWE) for mental health services remains underutilized. Mental health care often involves individualized treatment pathways, making it challenging to systematically study treatment adherence, symptom severity, functional outcomes, and long-term impacts. Inconsistent tracking of these outcomes in RWD sources presents challenges for evaluating treatment effectiveness. This research topic seeks to address these gaps by promoting the use of advanced methodologies, such as target trial emulation and causal inference techniques, to derive robust insights and strengthen causal conclusions from RWD. Additionally, advanced analytics, including the application of large language models, offers new opportunities to extract meaningful patterns and enhance the granularity of RWD analyses. By integrating these innovative approaches, researchers can bridge the gap between controlled clinical trials and real-world practice, enabling evidence-based decision-making that optimizes patient outcomes, informs policy, and drives the evolution of mental health services. Contributions are invited to advance methodological frameworks, explore novel applications, and address ethical considerations, such as privacy, data security, and algorithmic bias, to ensure the responsible use of RWD in mental health research.

This Research Topic focuses on leveraging RWD to advance mental health services research, with an emphasis on applied and methodological studies that utilize robust analytical techniques. Of particular interest are studies employing advanced methodologies, such as target trial emulation and causal inference techniques, to derive reliable and actionable insights into treatment adherence, symptom severity, functional outcomes, long-term impacts, and relapse prevention. Manuscripts integrating advanced data analytics, machine learning, and large language models to enhance the utility of RWD in evaluating the delivery of treatments and services are highly encouraged. Additionally, studies addressing challenges in systematically tracking mental health outcomes within RWD sources are welcome. Only studies using rigorous and validated methodologies will be considered. Ethical considerations, including privacy, data security, and algorithmic bias, are also central to this topic. We invite original research articles, systematic reviews, meta-analyses, methodological papers, and perspective pieces that contribute to the advancement of RWD-based mental health services research.

Topic Editor Alex Vance is employed by Holmusk USA, Inc. and also has equity ownership in Holmusk. The other Topic Editors report no competing interests related to this Research Topic.

Research Topic Research topic image

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Community Case Study
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: real world data, real world evidence, mental health services, treatment effectiveness, innovative methods

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 164Topic views
View impact