Neurovascular variations are highly prevalent, encompassing differences in origin, course, and vascular territories, which may result in atypical clinical manifestations. Importantly, these variations are not random; rather, they follow specific patterns rooted in embryonic development. Neuro-interventionalists frequently encounter such variations during the management of neurovascular diseases. A thorough understanding of these developmental variations is essential for informed surgical decision-making. However, the current clinical landscape shows insufficient attention to neurovascular variations, potentially leading to misdiagnosis and suboptimal treatment approaches. In the early stages of interventional neuroradiology, numerous researchers laid the groundwork by investigating the embryonic development of neurovascular structures. In the era of precision medicine, identifying neurovascular variations in clinical practice, elucidating their developmental origins, and summarizing their patterns and clinical implications are vital—not only for disease comprehension but also for enhancing surgical precision. Therefore, we propose this Research Topic to establish a platform for documenting these valuable yet often overlooked neurovascular variations and to further explore their embryological basis and developmental processes.
This Research Topic aims to cover all types of developmental variations within the neurovascular system. Contributors are encouraged to present the characteristics of vascular variations accompanied by imaging examples, schematic diagrams, descriptions of the embryonic developmental processes, and explanations of their significance in clinical practice.
To improve comprehension of developmental variations associated with neurovascular diseases, this Research Topic encompasses a comprehensive range of themes. We welcome Case Report, Clinical Trial, Data Report, Methods, Mini Review, Opinion, Original Research, Perspective, Review, Study Protocol, and Systematic Review that address topics including but not limited to: o Case presentations illustrating typical neuroimaging, embryonic developmental processes, and the clinical significance of developmental variations in neurovascular diseases. It should be noticed that case reports should be novel and include a review of the literature to address the significance and importance of variations for the precise treatment of neurovascular diseases. o Novel therapeutic strategies for developmental variations in neurovascular diseases. o Original Research and all types of Reviews focusing on the characteristics of specific developmental variations (i.e. nature history, incidence, mechanism, clinical significance, etc.). o Personalized treatments to improve patients’ diagnosis accuracy and treatment outcomes
Article types and fees
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Brief Research Report
Case Report
Clinical Trial
Editorial
FAIR² Data
FAIR² DATA Direct Submission
General Commentary
Hypothesis and Theory
Methods
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Article types
This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
