Advances in Mechanical Thrombectomy Devices for Acute Ischemic Stroke: From First-Generation to Next-Generation Innovation

Background and Scope

Mechanical thrombectomy has revolutionized the management of acute ischemic stroke (AIS), especially in cases of large vessel occlusion (LVO). Since the landmark trials in 2015, rapid evolution in thrombectomy devices has continued to redefine endovascular stroke therapy. From first-generation stent retrievers and aspiration catheters to newer combination devices and robotic systems, innovations in design, materials, and procedural strategies have significantly improved recanalization rates and clinical outcomes. Despite these advances, several clinical and technological questions remain: Which devices offer the best efficacy and safety profiles? How does clot composition influence device selection? What are the optimal strategies for achieving first-pass success? How do emerging technologies like AI integration, smart catheters, and robotic systems shape the future of thrombectomy?

This Research Topic aims to gather cutting-edge research, expert perspectives, and clinical experiences related to the evolution and performance of mechanical thrombectomy devices in AIS. We welcome multidisciplinary contributions from clinicians, interventional neurologists, engineers, researchers, and industry experts to provide a comprehensive view of where the field stands and where it's headed.

Potential Themes and Subtopics

We invite submissions in the form of original research, systematic reviews, clinical trials, perspectives, and case series focused on (but not limited to):

• Comparative efficacy and safety of various thrombectomy devices (stent retrievers, aspiration catheters, combination techniques)

• Innovations in device design and materials for improved clot retrieval and vessel safety

• Techniques and strategies for optimizing first-pass effect

• Role of clot characteristics and vessel anatomy in device selection

• Thrombectomy in challenging scenarios (tandem occlusions, posterior circulation, extended windows)

• Future directions: robotics, AI-guided thrombectomy, and smart navigation systems

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Classification
• Clinical Trial
• Community Case Study
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: Mechanical thrombectomy, acute ischemic stroke (AIS), large vessel occlusion (LVO), stent retrievers, aspiration catheters, device innovation, first-pass effect, robotics and AI in stroke intervention

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.