Tuberculosis: Recent Updates in Basic Research, Drug Discovery and Treatment - Volume II

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About this Research Topic

Submission deadlines

  1. Manuscript Summary Submission Deadline 28 February 2026 | Manuscript Submission Deadline 31 March 2026

  2. This Research Topic is currently accepting articles.

Background

Building on the success of "Tuberculosis: Recent Updates in Basic Research, Drug Discovery and Treatment", we are pleased to announce the launch of Volume II.

Tuberculosis (TB) continues to be one of the deadliest infectious diseases, ranking among the top ten worldwide according to the World Health Organisation (WHO). Despite progress in developing new anti-tubercular treatments and combinatorial therapies, significant challenges remain, particularly due to the severe side effects associated with these treatments.

The recent COVID-19 pandemic has further exacerbated the situation, causing major setbacks in global TB programs. These challenges necessitate a revaluation of the goals and milestones of the WHO's 'End TB Strategy' to ensure meaningful progress in combating this global epidemic.

This Research Topic aims to advance both clinical and basic research in TB treatment, disease management, and drug discovery, with a specific focus on understanding the metabolic remodelling of Mycobacterium tuberculosis in response to various drugs. By addressing these critical areas, we aim to make significant strides in the diagnosis, treatment, and control of TB worldwide. The goal is to uncover novel insights into the pathogen's biology and develop more effective therapeutic strategies, ultimately leading to improved management of TB.

To gather further insights within this scope, we welcome articles addressing, but not limited to, the following themes:

• Investigations of pathogenesis and determinants of TB
• Comprehensive investigations into treatment/drug discovery (and/or development) against pulmonary TB
• Advancements in vaccines and diagnostic methodologies for TB
• Innovative therapeutic approaches for patients with MDR/XDR TB
• Explorations into the molecular and genetic underpinnings of mycobacteria in the context of metabolic responses to various drugs/lead molecules

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Community Case Study
  • Conceptual Analysis
  • Curriculum, Instruction, and Pedagogy
  • Data Report
  • Editorial

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Tuberculosis, Mycobacterium tuberculosis, Drug Discovery, Clinical Trials, Treatment, Disease management, Drug Resistance

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

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