Biomolecular Condensates: From Fundamental Principles to Therapeutic Opportunities

This Research Topic invites original research, reviews, and perspectives inspired by the inaugural conference on biomolecular condensates, jointly sponsored by Frontiers in Biophysics and Frontiers in Molecular Biosciences. The aim is to capture state-of-the-art discoveries and foster cross-disciplinary dialogue on the mechanisms, functions, and therapeutic potential of biomolecular condensates in health and disease.

We seek contributions that address the biochemical and biophysical principles governing condensate formation, their roles in genome organization, cell signaling, stress responses, neurodegeneration, and cancer, as well as emerging methods to manipulate phase transitions for biomedical innovation. Of particular interest are works exploring RNA-driven phase separation, in vitro and cellular models revealing condensate dynamics, and approaches for condensate-targeted drug discovery.

Submissions covering new technologies, computational insights, engineered condensates, aging and amyloidogenesis, and case studies linking condensate biology to disease are especially welcome.

By bringing together leading voices from biophysics, structural biology, molecular biosciences, and drug discovery, this collection aims to chart the frontiers of biomolecular condensate research and inspire future breakthroughs.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Data Report
• Editorial
• FAIR² Data
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy Brief
• Review
• Systematic Review
• Technology and Code

Keywords: biomolecular condensates, phase separation, LLPS, stress response, transcription, c-mod, condensatoapthy

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.