Frontiers in Biophysics

Original Research

Published on 13 Aug 2026

Revealing intermediate states of voltage-gated potassium channels with physics-informed deep learning: application to Kv7.1

in Protein Structure and Dynamics

Julia Kacher
Mounir Tarek

Frontiers in Biophysics

doi 10.3389/frbis.2026.1877588

576 views

Review

Published on 12 Aug 2026

Silent Kv subunits as major players in cell membrane excitability

in Membrane Pores, Channels, and Transporters

Mohammed Alshemery
Mert Beyazyildirim
Joao L. Carvalho-de-Souza

Frontiers in Biophysics

doi 10.3389/frbis.2026.1925801

274 views

Mini Review

Accepted on 11 Aug 2026

Recent advances in mass spectrometry methods for the investigation of oligomeric intermediates of amyloid protein aggregation

in Protein Structure and Dynamics

Carlo Santambrogio
Erika Ponzini
Frank Sobott
Rita Grandori

Frontiers in Biophysics

Mini Review

Accepted on 11 Aug 2026

Beyond RNA/DNA: Exploring the Emerging Role of Poly(ADP-ribose): Structure, Function, and Condensate Formation

in Coacervates and Biological Condensates

Lipika Baidya
Hung Nguyen

Frontiers in Biophysics

Mini Review

Published on 06 Aug 2026

Probing peptide-mediated membrane pore formation by fluorescence, infrared spectroscopy, and atomic force microscopy

in Membrane Pores, Channels, and Transporters

Suren A. Tatulian
Munira Haque

Frontiers in Biophysics

doi 10.3389/frbis.2026.1870174

360 views

Original Research

Published on 06 Aug 2026

Targeting cancer matrix mechanics: fibronectin fiber relaxation correlates with ADAM8 expression in PDAC and is amenable to in vitro modulation

in Mechanotransduction and Mechanobiology

Konstantin M. P. Wolf
Lea S. Ottenwald
Martin Wartenberg
Mamta Chabria
Viola Vogel

Frontiers in Biophysics

doi 10.3389/frbis.2026.1781425

582 views

Perspective

Accepted on 03 Aug 2026

Biomolecular condensates, emergent properties, and the mesoscale concept gap

in Coacervates and Biological Condensates

Jeremy David Schmit

Frontiers in Biophysics

180 views

Editorial

Published on 24 Jul 2026

Editorial: Structural and functional roles of membrane transport proteins in cellular physiology

in Membrane Pores, Channels, and Transporters

Olga Vinogradova

Frontiers in Biophysics

doi 10.3389/frbis.2026.1926644

314 views

Perspective

Accepted on 20 Jul 2026

IDRs lead the way: Cooperativity between intrinsically disordered regions and structured interaction domains drives enrichment in transcription condensates

in Coacervates and Biological Condensates

Arad Abazari
Dinitha Y. Caldera
Alisha Budhathoki
Ganesh Pandey
Mehdi Shafiei Aporvari
Filmon A. Medhanie
Jan-Hendrik Spille

Frontiers in Biophysics

255 views

Original Research

Published on 14 Jul 2026

From scattering curves to structural descriptors: interpretable machine learning maps SAXS/WAXS signals to RNA structural details in defined RNA motifs

in Mechanotransduction and Mechanobiology

Weiwei He
Serdal Kirmizialtin

Frontiers in Biophysics

doi 10.3389/frbis.2026.1769000

584 views

Mini Review

Published on 10 Jul 2026

Intrinsically disordered regions as drivers of protein aggregation: mechanisms, phase separation, and emerging predictive frameworks

in Protein Structure and Dynamics

Rahul Kaushik
Suyong Re

Frontiers in Biophysics

doi 10.3389/frbis.2026.1880887

865 views

Original Research

Published on 08 Jul 2026

Chromatic discrimination in protocells toward proto vision and intelligence

in Coacervates and Biological Condensates

Panagiotis Mougkogiannis
Andrew Adamatzky

Frontiers in Biophysics

doi 10.3389/frbis.2026.1839006

857 views
1 citation

Hypothesis and Theory

Published on 08 Jun 2026

Threshold transitions of 15N fluxes reveal state-dependent root conductance and flux partitioning within steady-state nitrate isotherms

in Membrane Pores, Channels, and Transporters

Erwan Le Deunff
Philippe Malagoli

Frontiers in Biophysics

doi 10.3389/frbis.2026.1677942

1,382 views

Mini Review

Published on 01 Jun 2026

Biomolecular condensation meets membrane biophysics: from interfacial physical principles to emerging therapeutic opportunities

in Coacervates and Biological Condensates

Agustín Mangiarotti
Ernesto E. Ambroggio
M. Soledad Celej

Frontiers in Biophysics

doi 10.3389/frbis.2026.1860065

1,283 views

Original Research

Published on 04 May 2026

Linker peptide acts as an external mechanical clamp in a designed polyprotein

in Mechanotransduction and Mechanobiology

Yanwei Wang
Bin Zheng
Peng Zheng

Frontiers in Biophysics

doi 10.3389/frbis.2026.1808825

1,292 views

Review

Published on 01 Apr 2026

Novel therapeutic approaches targeting biomechanical pathway alterations in bone diseases

in Mechanotransduction and Mechanobiology

Malkiet Kaur
Manju Nagpal

Frontiers in Biophysics

doi 10.3389/frbis.2026.1773451

1,458 views

Mini Review

Published on 25 Mar 2026

From the classical colloidal theory to biomolecular condensation: implications in health and disease

in Coacervates and Biological Condensates

Noelia A. Melian
Aldana Gomez
Milagros B. Abate
Pamela L. Toledo
Mario R. Ermácora
Diego S. Vazquez

Frontiers in Biophysics

doi 10.3389/frbis.2026.1795884

1,945 views

Review

Published on 09 Mar 2026

IDRs in Cross-Membrane Transport: Regulation of Ion Channels and Transporters, Mechanistic Studies Made Possible by NMR and Computational Methods

in Membrane Pores, Channels, and Transporters

Olga Vinogradova

Frontiers in Biophysics

doi 10.3389/frbis.2026.1804302

1,742 views

Original Research

Published on 08 Jan 2026

Functional study of a novel SCN4A variant c.611C>T identified in a Japanese patient with myasthenia

in Membrane Pores, Channels, and Transporters

Natsuki Kira
Kosuke Yoshida
Satoe Takahashi
Ayami Yamanaka
Takashi Kimura
Kazuaki Homma
Masanori P. Takahashi
Tomoya Kubota

Frontiers in Biophysics

doi 10.3389/frbis.2025.1710099

1,547 views

Review

Published on 03 Dec 2025

A blurry view of fuzzy objects: on the roles of low-resolution structural techniques in discovery and early characterization of intrinsically disordered proteins

in Protein Structure and Dynamics

Vladimir N. Uversky

Frontiers in Biophysics

doi 10.3389/frbis.2025.1693360

5,594 views
1 citation

Review

Published on 30 Oct 2025

Vesicular and plasma membrane glutamate transporters

in Membrane Pores, Channels, and Transporters

Bart Borghans
Natalia Dmitrieva
Aleksandr Nikiforov
Christoph Fahlke

Frontiers in Biophysics

doi 10.3389/frbis.2025.1693508

3,344 views
3 citations

Mini Review

Published on 08 Oct 2025

Proton channel Hv1 modulates microglial responses to neurological disorders

in Membrane Pores, Channels, and Transporters

Maite Stratmann
Caterina Gagliardi
Melania Capasso

Frontiers in Biophysics

doi 10.3389/frbis.2025.1681011

3,508 views

Original Research

Published on 02 Oct 2025

Identification of voltage-gated calcium currents in Helix (Cornu) serotonergic neurons, subcellular localization, and role in calcium dynamics and cellular firing of CaV2.1 and CaV2.2 subtypes

in Membrane Pores, Channels, and Transporters

María Laura Ríos-Reyes
Silvia Calvo-Corea
Oscar Brenes

Frontiers in Biophysics

doi 10.3389/frbis.2025.1652466

2,077 views

Review

Published on 18 Sep 2025

From biophysics to cellular function: neural TELCs-membrane-anions capacitor transmembrane potential

in Membrane Pores, Channels, and Transporters

James Weifu Lee

Frontiers in Biophysics

doi 10.3389/frbis.2025.1648934

2,234 views
3 citations

38 articles

articles

Revealing intermediate states of voltage-gated potassium channels with physics-informed deep learning: application to Kv7.1

Silent Kv subunits as major players in cell membrane excitability

Recent advances in mass spectrometry methods for the investigation of oligomeric intermediates of amyloid protein aggregation

Beyond RNA/DNA: Exploring the Emerging Role of Poly(ADP-ribose): Structure, Function, and Condensate Formation

Probing peptide-mediated membrane pore formation by fluorescence, infrared spectroscopy, and atomic force microscopy

Targeting cancer matrix mechanics: fibronectin fiber relaxation correlates with ADAM8 expression in PDAC and is amenable to in vitro modulation

Biomolecular condensates, emergent properties, and the mesoscale concept gap

Editorial: Structural and functional roles of membrane transport proteins in cellular physiology

IDRs lead the way: Cooperativity between intrinsically disordered regions and structured interaction domains drives enrichment in transcription condensates

From scattering curves to structural descriptors: interpretable machine learning maps SAXS/WAXS signals to RNA structural details in defined RNA motifs

Intrinsically disordered regions as drivers of protein aggregation: mechanisms, phase separation, and emerging predictive frameworks

Chromatic discrimination in protocells toward proto vision and intelligence

Threshold transitions of 15N fluxes reveal state-dependent root conductance and flux partitioning within steady-state nitrate isotherms

Biomolecular condensation meets membrane biophysics: from interfacial physical principles to emerging therapeutic opportunities

Linker peptide acts as an external mechanical clamp in a designed polyprotein

Novel therapeutic approaches targeting biomechanical pathway alterations in bone diseases

From the classical colloidal theory to biomolecular condensation: implications in health and disease

IDRs in Cross-Membrane Transport: Regulation of Ion Channels and Transporters, Mechanistic Studies Made Possible by NMR and Computational Methods

Functional study of a novel SCN4A variant c.611C>T identified in a Japanese patient with myasthenia

A blurry view of fuzzy objects: on the roles of low-resolution structural techniques in discovery and early characterization of intrinsically disordered proteins

Vesicular and plasma membrane glutamate transporters

Proton channel Hv1 modulates microglial responses to neurological disorders

Identification of voltage-gated calcium currents in Helix (Cornu) serotonergic neurons, subcellular localization, and role in calcium dynamics and cellular firing of CaV2.1 and CaV2.2 subtypes

From biophysics to cellular function: neural TELCs-membrane-anions capacitor transmembrane potential