Chief Editor Selected Contributions and Emerging Perspectives on Cellular Senescence in Aging Research

Cellular senescence, an area of intensive investigation in aging research, has shown significant progress in recent years. The study of cellular senescence comprises an understanding of how cells lose their ability to divide and how this then impacts aging processes and the development of age-related diseases. Although recent studies have shed light on molecular mechanisms and regulatory pathways governing cellular senescence, it remains a highly dynamic field with many unanswered questions. Furthermore, the challenge remains in translating these basic research insights into clinical applications for managing aging and related diseases.

This Research Topic aims to bring together cutting-edge research and expert perspectives on cellular senescence to highlight the latest breakthroughs, standing challenges, and innovative opportunities that define the current landscape of this field. By collating insights from leading scientists hand-picked by Prof. Lea Harrington, this collection seeks to provide a forum for discussing critical questions essential for advancing our understanding of cellular senescence. Contributors are encouraged to elucidate the state of the art in their research area, identify persistent challenges, discuss strategies to address these, and share visions for future trajectories of cellular senescence research, especially concerning its relationship to aging biology.

The scope of this Research Topic spans broad inquiries while maintaining focus on the field of cellular senescence. Contributors are welcome to submit articles that address topics including, but not limited to, the following themes:

- Mechanistic insights into cellular senescence and its regulation.
- Novel methodologies and technologies in aging and senescence research.
- The role of senescence in age-associated diseases.
- Potential therapeutic interventions targeting cellular senescence.
- Future challenges and directions in the intersection of senescence and aging.

This collection endeavors to be a vital resource that not only celebrates past achievements but also outlines a research roadmap for future innovations in the field of cellular senescence. Through contributions from our highly esteemed editorial board and noted researchers, we aim to inspire continued excellence and exploration.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Cellular senescence, Aging, Age-associated diseases, Mechanistic insights, Therapeutic interventions, Molecular Mechanisms

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.