Gene Expression Profiling and Editing in Disease: Omics Technologies in Action

Gene expression analysis is undergoing a profound transformation, driven by the rapid evolution of advanced omics technologies. From single-cell transcriptomics to spatial omics, from functional genomics to integrative epigenetics, researchers now have powerful tools to explore the complex regulatory networks underlying cellular function.

Understanding how gene expression is altered in pathological conditions—such as cancer, rare genetic disorders, neurological diseases, and inflammatory states—is crucial for identifying early biomarkers, discovering therapeutic targets, and developing personalized interventions.

This Research Topic aims to become a key reference for researchers working at the intersection of omics technologies, molecular biology, bioinformatics, and gene therapy. We seek to collect high-impact contributions that demonstrate how emerging omics approaches are redefining the study of gene expression under both physiological and pathological conditions.

We welcome studies that explore the therapeutic potential of gene modulation, integrating multi-omics analyses, cutting-edge computational methods. By bringing together interdisciplinary expertise, this collection aims to foster innovation in the understanding and targeted correction of gene expression in human disease.

We are seeking motivated researchers, visionary ideas, and multidisciplinary projects. If you are working with advanced technologies to decipher—or correct—gene expression, this is the ideal platform to showcase your contribution.

We welcome:

• Original research articles presenting innovative findings

• Comprehensive reviews on emerging topics

• Methodologies and protocols for omics data analysis and integration

• Short communications and high-impact case studies

All submissions will undergo rigorous peer review and will be included in a collection designed to maximize visibility, citations, and foster international collaborations.

Authors are encouraged to emphasize the translational potential of their work and to highlight novel insights into gene expression regulation and therapeutic strategies. Interdisciplinary approaches combining experimental and computational methods are particularly welcome.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Editorial
• FAIR² Data
• FAIR² DATA Direct Submission
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy Brief
• Review
• Technology and Code

Keywords: gene expression profiling, omics, gene therapy, bioinformatics, cancer, rare genetic disorders, neurological disease, inflammation

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.