Research Topic

Impact of Natural Antioxidants on Vascular Cells' Regenerative Potential

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A growing body of evidence indicates that oxidative stress-induced vascular damage is a crucial factor in the pathogenesis of cardiovascular diseases (CVD). In this context, the term "vascular oxidative stress" refers to increased levels of reactive oxygen species (ROS) within the vascular wall, where ...

A growing body of evidence indicates that oxidative stress-induced vascular damage is a crucial factor in the pathogenesis of cardiovascular diseases (CVD). In this context, the term "vascular oxidative stress" refers to increased levels of reactive oxygen species (ROS) within the vascular wall, where production is due to the diseases-associated aberrant functioning of several ROS-generating enzymes, including NADPH oxidase, the mitochondrial electron transport system, uncoupling of endothelial NO synthase (eNOS) and cytochrome p450.

Natural antioxidants (NA) from vegetable foods and some beverages appears to counteract oxidative stress, and their intake has been associated with a reduced incidence of risk factors for CVD. It has indeed been hypothesized that NA consumption, by preventing ROS-induced oxidative damage would preserve vascular cells functions thus reducing the occurrence of cardiovascular events. Nonetheless, many clinical trials have failed to demonstrate that increased NA consumption has a protective action against CVD and the reason for these disappointing findings is so far unclear.

ROS can have a dual action within the cells, modulating both pro- and anti-survival signals, hence therapeutic approaches aimed at ROS suppression might have the unexpected consequences of negatively impacting vascular cells functions. Furthermore, NA may act as pro-oxidants under particular conditions and paradoxically increase ROS generation and elicit cell damage. In this light, antioxidant-based strategies based on the counteraction of intracellular ROS, to prevent vascular cell functions, may have the untoward effect of leading to vascular damage.
The aim of this Research Topic is to attract original research articles, clinical studies, and review articles dealing with this particular aspect of NA. Therefore, we welcome authors to submit manuscripts that explore, discuss or comment data concerning the impact of NA on the regenerative potential of vascular cells.

Potential arguments may include, but are not limited to, the following:
Impact of NA on angiogenesis, vasculogenesis and vascular remodeling;
Impact of NA on vascular homeostasis, blood loss, platelet activation and their interaction with leukocytes and vascular cells in general;
Impact of NA on endothelial cells and vascular smooth muscle cells functions and behavior (e.g. proliferation, migration, differentiation, phenotypic switch);
Impact of NA on perivascular cells such as pericytes and adventitial perivascular cells (e.g. fibroblasts and adipocytes);
Impact of NA on endothelial progenitor cell and other bone marrow-originated cells; and
Impact of NA on cardiac stem cells proliferation and cardiac regeneration.


Keywords: Reactive Oxygen Species, Oxidative stress, Natural Antioxidants, Endothelium, Vasculature, Vascular cells, Endothelial progenitor cell, Cardiac Stem Cells, Regenerative Potential


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