About this Research Topic
Recent evidence has revealed that microvascular endothelial cells and companion pericytes play an active and dynamic role in driving or shaping cardiac remodeling.
Various mechanisms are involved, including the release of paracrine factors, reactive oxygen species, microparticles, non‐coding RNAs, and chemokines. These agents may serve to maintain normal cardiac ultrastructure and function, or cause changes that undermine heart function. The “canonical” concept of microvascular endothelium, considered a passive bystander or innocent victim of cardiomyocyte‐driven remodeling events that occur with various assaults or injuries of the heart, is now changing.
The goal of this Research Topic is to highlight recent developments in this emerging area of heart research by compiling review articles and original research studies.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.