Pathogenicity Assessment | List of Frontiers open access articles

Original Research

Published on 08 Oct 2025

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

in Neurogenomics

Xin Wang
Zelin Wu
Shaoli Wei
Xinran Zhao
Juan Lin
Fang Zhao
Xiaolei Liu

Frontiers in Genetics

doi 10.3389/fgene.2025.1676565

537 views

Original Research

Published on 08 Oct 2025

Development of an AI-driven digital assistance system for real-time safety evaluation and quality control in laparoscopic liver surgery

in Cancer Imaging and Image-directed Interventions

Zi-Yang Peng
Zhi-Bo Wang
Yan Yan
Hao-Qian Peng
Yong-Tai Ma
Yu-Tong Li
Yao-Xing Ren
Jun-Xi Xiang
Kun Guo
Gang Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1678525

600 views

Review

Published on 08 Oct 2025

Enzymatic post-translational modifications of proteins in chronic kidney disease: mechanisms, regulation, and clinical significance

in Renal Pharmacology

Minlong Wei
Jinyun Lin
Yi Zeng
Xiaojuan Wang
Jialu Wen
Jing Wang
Wei Zou
Kang Tu
Menghua Liu
Juan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678812

970 views

Systematic Review

Published on 08 Oct 2025

Comparative effectiveness of GLP-1 receptor agonists and dual agonists in the treatment of patients with metabolic dysfunction associated steatohepatitis: a systematic review and meta-analysis

in Cardiovascular Endocrinology

Meng Li
Jianli Hu
Yip Han Chin
Han Shi Jocelyn Chew
Wenru Wang

Frontiers in Endocrinology

doi 10.3389/fendo.2025.1681965

764 views

Original Research

Published on 08 Oct 2025

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

in Comparative Immunology

Hicham Sid
Theresa von Heyl
Sabrina Schleibinger
Romina Klinger
Leah Heymelot Nabel
Hanna Vikkula
Rodrigo Guabiraba
Vanaique Guillory
Ryan Scicluna
Mohanned Naif Alhussien

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680791

847 views

Review

Published on 08 Oct 2025

Metabolic regulation of interferon-mediated innate antiviral immunity

in Viral Immunology

Tian Zhong
Qi Cao
Zhiyue Ma
Caiyu Jiang

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680688

763 views

Original Research

Published on 08 Oct 2025

Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target

in Cancer Immunity and Immunotherapy

Yadan Li
Xiaolong Tang
Wenhui Zhao
Xiuwen Si
Yanfang Cui
Yanbin Dong
Yongshuo Liu

Frontiers in Immunology

doi 10.3389/fimmu.2025.1680667

399 views

Review

Published on 08 Oct 2025

Clinical characteristics and risk factor analysis of overlapping syndromes of COPD-OSA with metabolic syndrome in middle-to-high altitude areas

in Pulmonary Medicine

Yisha Qin
Aniu Aju
Yilin Wan
Mengchen Song
Xingxing Hao
Jiwu Li
Xuefeng Shi

Frontiers in Medicine

doi 10.3389/fmed.2025.1680584

283 views

Review

Published on 08 Oct 2025

The tibialis anterior tendon revisited: a unified classification framework across development, evolution, and clinical application

in Evolutionary Developmental Biology

Łukasz Olewnik
Ingrid C. Landfald
Magdalena Ciechanowska
Bento João Abreu
Judney Cley Cavalcante

Frontiers in Cell and Developmental Biology

doi 10.3389/fcell.2025.1678982

718 views

Original Research

Published on 08 Oct 2025

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants

in Cancer Genetics

Hanan E. Alatwi
Amnah A. Alharbi
Rashid Mir
Othman R. Alzahrani
Abdulrahman H. Alessa
Yousef M. Hawsawi
Mohammed Ali Arishi
Aziz Dhaher Albalawi

Frontiers in Oncology

doi 10.3389/fonc.2025.1679528

1,192 views

Review

Published on 08 Oct 2025

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

in Brain Disease Mechanisms

Jarika Jahan Tumpa
Qurat Ul Ain Hayder
Nowshin Sharmily Maisa
Md. Nazmul Islam

Frontiers in Molecular Neuroscience

doi 10.3389/fnmol.2025.1682006

824 views

Original Research

Published on 08 Oct 2025

Dissecting adult plant resistance to stem rust through multi-model GWAS in a diverse barley germplasm panel

in Plant Genetics, Epigenetics and Chromosome Biology

Yuliya Genievskaya
Akerke Maulenbay
Shynbolat Rsaliyev
Saule Abugalieva
Aralbek Rsaliyev
Alibek Zatybekov
Yerlan Turuspekov

Frontiers in Plant Science

doi 10.3389/fpls.2025.1681398

1,427 views

Original Research

Published on 08 Oct 2025

A strategy for risk control of marine pollution from land-based sources: establishment of Multilateral Guarantee Mechanism

in Marine Pollution

Xiaolin Pan

Frontiers in Marine Science

doi 10.3389/fmars.2025.1681518

1,027 views

Original Research

Published on 08 Oct 2025

Prediction of compressive strength of high-performance concrete based on multiple machine learning models

in Structural Materials

Kouchen Xiao
Hongjian Zhang
Sijia Wei
Chuanxin Zhu
Jingtong He
Shuai Zhu
Xiaohan Yang

Frontiers in Materials

doi 10.3389/fmats.2025.1698248

530 views

Original Research

Published on 08 Oct 2025

A digital twin of glimepiride for personalized and stratified diabetes treatment

in Pharmacogenetics and Pharmacogenomics

Michelle Elias
Matthias König

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1686415

720 views

Perspective

Published on 08 Oct 2025

The environmental price of diagnostic scale-up—addressing a toxic trade-off we cannot afford

in Environmental Sensors, Sustainability and Reaching Net-Zero

Collins Otieno Odhiambo
Beatrice Van Puije
Edward Krisiunas
Anafi Mataka

Frontiers in Lab on a Chip Technologies

doi 10.3389/frlct.2025.1693514

168 views

Articles

Integrated transcriptomic and single-cell RNA sequencing identifies lysosomal ion channel genes as potential biomarkers for Alzheimer’s disease

Development of an AI-driven digital assistance system for real-time safety evaluation and quality control in laparoscopic liver surgery

Enzymatic post-translational modifications of proteins in chronic kidney disease: mechanisms, regulation, and clinical significance

Comparative effectiveness of GLP-1 receptor agonists and dual agonists in the treatment of patients with metabolic dysfunction associated steatohepatitis: a systematic review and meta-analysis

Genetic reinstatement of RIG-I in chickens reveals insights into avian immune evolution and influenza interaction

Metabolic regulation of interferon-mediated innate antiviral immunity

Ribosome biogenesis-related gene signature predicts prognosis and immune landscape in glioma and identifies UTP20 as a therapeutic target

Clinical characteristics and risk factor analysis of overlapping syndromes of COPD-OSA with metabolic syndrome in middle-to-high altitude areas

The tibialis anterior tendon revisited: a unified classification framework across development, evolution, and clinical application

Whole-exome sequencing in Saudi colorectal cancer patients reveals distinct mutational patterns and population specific pathogenic variants

Peripheral–central immune interactions in Parkinson’s disease: insights into innate and adaptive immunity

Dissecting adult plant resistance to stem rust through multi-model GWAS in a diverse barley germplasm panel

A strategy for risk control of marine pollution from land-based sources: establishment of Multilateral Guarantee Mechanism

Prediction of compressive strength of high-performance concrete based on multiple machine learning models

A digital twin of glimepiride for personalized and stratified diabetes treatment

The environmental price of diagnostic scale-up—addressing a toxic trade-off we cannot afford