Preclinical Stage | List of Frontiers open access articles

Original Research

Published on 02 Sep 2025

Computational discovery of natural medicines targeting adenosine receptors for metabolic diseases

in Ethnopharmacology

Peng Wang
Zhiyu Xu
Yuqing Deng
Huiping Yuan
Yale Wu
Jing Jiang
Zhaohui Lyu
Zejun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1671415

303 views

Original Research

Published on 02 Sep 2025

Pan-cancer analysis reveals intratumoral microbial diversity in multiple cancers by amplicon technology

in Extra-intestinal Microbiome

Xudong Liu
Yuteng Yao
Aoyi Xiao
Dingyan Cao
Jingheng Zhang
Yanan Shi
Qing Zhong
Zilong He
Wenming Wu

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1549319

194 views

Original Research

Published on 02 Sep 2025

Deliberative democracy as a tool to foster youth participation in Europe: the case of Citizens’ Juries in Sierra Norte

in Political Participation

Óliver Soto-Sainz

Frontiers in Political Science

doi 10.3389/fpos.2025.1605781

195 views

Original Research

Published on 02 Sep 2025

Separate and cumulative effect of risk and protective factors associated with suicidal ideation among Chinese infertile couples: a cross-sectional study

in Health Psychology

Jijie Chen
Jieke Li
Yaqiong Liu
Xiuqing Song
Xiaoyan Yuan
Xuekun Zhang
Xiaoling Deng

Frontiers in Psychology

doi 10.3389/fpsyg.2025.1610027

261 views

Correction

Published on 02 Sep 2025

Correction: Fu's subcutaneous needling for knee osteoarthritis: a systematic review and meta-analysis

in Rheumatology

Xiaohu Zhao
Jingxuan Liu
Dake Li
Shangkun Si
Xuanhe Tian
Deke Zhang
Ping Jiang

Frontiers in Medicine

doi 10.3389/fmed.2025.1686449

174 views

Original Research

Published on 02 Sep 2025

Citrullinated peptides of peptidyl arginine deiminase 4 as major B-cell epitopes in patients with rheumatoid arthritis

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Mathilde Giassi
Eric Toussirot
Nathalie C. Lambert
Jean Roudier
Isabelle Auger

Frontiers in Immunology

doi 10.3389/fimmu.2025.1640291

189 views

Editorial

Published on 02 Sep 2025

Editorial: Networks and graphs in biological data: current methods, opportunities and challenges

in Network Bioinformatics

Derek L. Thompson
Hsiang-Yun Wu
Christopher W. Bartlett
William C. Ray

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1685992

321 views

Original Research

Published on 02 Sep 2025

Biodiversity conservation and management through forest landscape restoration in the Western Himalaya, India

in Plant Conservation

Vikram S. Negi
Ravi Pathak
Bhawna Dangwal
Ravindra K. Joshi
Subodh Airi
K. C. Sekar
Shreekar Pant
Indra D. Bhatt
S. S. Samant

Frontiers in Conservation Science

doi 10.3389/fcosc.2025.1663322

353 views

Original Research

Published on 02 Sep 2025

A quantitative comparative analysis of the Four Medical Tantras of Tibetan medicine and the As⋅ṭān˙ga Hṛdaya Saṃhitā of Ayurveda: a focus on diet, medicinal materials, and preparations

in Ethnopharmacology

Zhuoma Garang
Gebai Zhaxi
Zhuoma Suonan
Mejia La
Rizhun Luo
Bai Bai
Lame Lizhen
Jingwen Zhang
Tsedien Nhamdriel
Silang Jiangyong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595646

163 views

Original Research

Published on 02 Sep 2025

Breastfeeding practices and challenges in women with breast implants in Saudi Arabia: a descriptive study

in Maternal Health

Abeer Orabi

Frontiers in Global Women's Health

doi 10.3389/fgwh.2025.1647351

310 views

Review

Published on 02 Sep 2025

Hypoxia and activation of hypoxia inducible factor alpha as influencers of inflammatory helper T cells in autoimmune disease – a link between cancer and autoimmunity

in Autoimmune and Autoinflammatory Disorders : Autoimmune Disorders

Giovanni Almanzar
Juan Carlos Alarcon
Ruth Garzon
Ana Maria Navarro
Alejandro Ondo-Méndez
Martina Prelog

Frontiers in Immunology

doi 10.3389/fimmu.2025.1633845

154 views

Original Research

Published on 02 Sep 2025

Epidemiological features of tuberculosis infection in a high-altitude population: a population-based, cross-sectional survey in Tibet, China

in Bacteria and Host

Jian Wang
Shaojun Pei
Guofeng Yang
Nima Qucuo
Qifei Song
Xiaoqiu Liu
Xue Li
Wei Chen
Tao Li
Eryong Liu

Frontiers in Cellular and Infection Microbiology

doi 10.3389/fcimb.2025.1651920

133 views

Brief Research Report

Published on 02 Sep 2025

Assessment of gene signatures following the inhibition of IL-23: a study to evaluate the mechanistic effects behind the clinical efficacy of guselkumab in patients with psoriatic arthritis

in Autoimmune and Autoinflammatory Disorders: Autoinflammatory Disorders

Mirco Mastrangelo
Piero Ruscitti
Manfredo Bruni
Eleonora Lucantonio
Andrea De Berardinis
Antonio Barile
Maria Concetta Fargnoli
Paola Cipriani
Maria Esposito
Cristina Pellegrini

Frontiers in Immunology

doi 10.3389/fimmu.2025.1672667

243 views

Original Research

Published on 02 Sep 2025

Experiences with complementary and integrative medicine in mental healthcare: a qualitative substudy of the PSYKIM project

in Family Medicine and Primary Care

Julia Siewert
Hannah Wackermann
Benno Brinkhaus
Michael Teut
Eva Jansen

Frontiers in Medicine

doi 10.3389/fmed.2025.1629436

208 views

Case Report

Published on 02 Sep 2025

Case Report: Keeping the Milan approach legacy alive? Paradox and counterparadox working therapeutically with non-suicidal self-injury

in Developmental Psychopathology and Mental Health

Ferdinando Salamino
Elisa Gusmini

Frontiers in Child and Adolescent Psychiatry

doi 10.3389/frcha.2025.1657395

119 views

Original Research

Published on 02 Sep 2025

An injectable curcumin-loaded hydrogel for neuroprotective treatment promote nerve tissue repair in rat severe spinal cord injury

in Biomaterials

Zhaoqing Zhang
Haiyan Ma
Ruisong Tian
Guangwei Li
Fuchang Zhao
Liangyu Xie
Hao Chen

Frontiers in Bioengineering and Biotechnology

doi 10.3389/fbioe.2025.1655686

224 views

Articles

Computational discovery of natural medicines targeting adenosine receptors for metabolic diseases

Pan-cancer analysis reveals intratumoral microbial diversity in multiple cancers by amplicon technology

Deliberative democracy as a tool to foster youth participation in Europe: the case of Citizens’ Juries in Sierra Norte

Separate and cumulative effect of risk and protective factors associated with suicidal ideation among Chinese infertile couples: a cross-sectional study

Correction: Fu's subcutaneous needling for knee osteoarthritis: a systematic review and meta-analysis

Citrullinated peptides of peptidyl arginine deiminase 4 as major B-cell epitopes in patients with rheumatoid arthritis

Editorial: Networks and graphs in biological data: current methods, opportunities and challenges

Biodiversity conservation and management through forest landscape restoration in the Western Himalaya, India

A quantitative comparative analysis of the Four Medical Tantras of Tibetan medicine and the As⋅ṭān˙ga Hṛdaya Saṃhitā of Ayurveda: a focus on diet, medicinal materials, and preparations

Breastfeeding practices and challenges in women with breast implants in Saudi Arabia: a descriptive study

Hypoxia and activation of hypoxia inducible factor alpha as influencers of inflammatory helper T cells in autoimmune disease – a link between cancer and autoimmunity

Epidemiological features of tuberculosis infection in a high-altitude population: a population-based, cross-sectional survey in Tibet, China

Assessment of gene signatures following the inhibition of IL-23: a study to evaluate the mechanistic effects behind the clinical efficacy of guselkumab in patients with psoriatic arthritis

Experiences with complementary and integrative medicine in mental healthcare: a qualitative substudy of the PSYKIM project

Case Report: Keeping the Milan approach legacy alive? Paradox and counterparadox working therapeutically with non-suicidal self-injury

An injectable curcumin-loaded hydrogel for neuroprotective treatment promote nerve tissue repair in rat severe spinal cord injury