Your new experience awaits. Try the new design now and help us make it even better

ORIGINAL RESEARCH article

Front. Cell. Infect. Microbiol.

Sec. Extra-intestinal Microbiome

Volume 15 - 2025 | doi: 10.3389/fcimb.2025.1549319

This article is part of the Research TopicUnderstanding the Impact of Microbes on Tumor Progression and Prevention: Unveiling New Avenues for Cancer therapyView all 7 articles

Pan-cancer analysis reveals intratumoural microbial diversity in multiple cancers by amplicon technology

Provisionally accepted
Xudong  LiuXudong Liu1Yuteng  YaoYuteng Yao2Aoyi  XiaoAoyi Xiao3Dingyan  CaoDingyan Cao3Jingcheng  ZhangJingcheng Zhang3Yanan  ShiYanan Shi1Qing  ZhongQing Zhong1Zilong  HeZilong He4Wenming  WuWenming Wu1,3*
  • 1State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China
  • 2School of Life Sciences, Henan University, Kaifeng, Henan Province, China
  • 3Department of General Surgery, Peking Union Medical College Hospital (CAMS), Beijing, Beijing Municipality, China
  • 4School of Mechanical Engineering and Automation, Beihang University, Beijing, China

The final, formatted version of the article will be published soon.

Despite numerous studies investigating intratumoral microorganisms and their significant roles in cancer initiation, progression, and treatment efficacy, a systematic understanding of intratumoral microorganisms remains lacking. Herein, we conducted a study using 16S rDNA data on seven types of cancer, comprising a total of 783 samples. It's worth noting that Pseudomonas, Streptococcus, and Prevotella were found to be shared with the microbial communities of the seven cancers, suggesting that these may be associated with the occurrence and development of cancers. We anticipate establishing a foundation for related research and exploring potential methods for cancer treatment.

Keywords: Pan-cancer, intratumoural microbial, 16S rDNA, Pseudomonas, Streptococcus, Prevotella

Received: 09 Jan 2025; Accepted: 05 Aug 2025.

Copyright: © 2025 Liu, Yao, Xiao, Cao, Zhang, Shi, Zhong, He and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Wenming Wu, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.