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ORIGINAL RESEARCH article

Front. Clin. Diabetes Healthc.
Sec. Diabetes Nutrition and Dietetics
Volume 5 - 2024 | doi: 10.3389/fcdhc.2024.1399410
This article is part of the Research Topic An Integrated Approach: Nutrition Strategies for People with Diabetes View all articles

Postprandial glycemic response to high protein diabetes specific nutritional shake compared to iso-caloric instant oatmeal in people with type 2 diabetes -a randomized, controlled, crossover trial

Provisionally accepted
Sara Thomas Sara Thomas 1*Beth Besecker Beth Besecker 1Yong Choe Yong Choe 1Elena A. Christofides Elena A. Christofides 2
  • 1 Abbott (United States), Chicago, United States
  • 2 Endocrinology Associates, Columbus, United States

The final, formatted version of the article will be published soon.

    Minimizing postprandial glucose response is an important goal for overall diabetes management. Diabetes specific nutritional shakes (DSNS) are clinically shown to minimize postprandial glucose response in people with type 2 diabetes (T2DM) compared to high glycemic foods. However, it is unknown how a high-protein, low-fat DSNS impacts GLP-1 response. We tested the postprandial glucose, insulin, and GLP-1 response to a high protein, low-fat diabetes specific nutritional shake (DSNS-HP) compared to isocaloric instant oatmeal (IOM) in a randomized, controlled, crossover study in adults with T2DM (n = 24). Participants were randomized to receive IOM or DSNS-HP on two test days. Glucose, insulin, and total GLP-1 concentration were measured at baseline and 15, 30, 45, 60, 90, 120, 180, and 240 minutes postprandially. Compared to IOM, glucose positive area under the curve (pAUC) was significantly lower (P = .021). DSNS-HP significantly increased GLP-1 pAUC response by 213% (P < .001) with a corresponding increase in insulin pAUC (P = .033) compared to IOM. A high protein, low-fat DSNS leads to favorable changes in GLP-1 response and is a suitable option to minimize blood glucose response in people with type 2 diabetes.

    Keywords: Diabetes1, postprandial glucose2, GLP-13, nutrition4, protein5

    Received: 11 Mar 2024; Accepted: 30 Apr 2024.

    Copyright: © 2024 Thomas, Besecker, Choe and Christofides. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Sara Thomas, Abbott (United States), Chicago, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.