Crosstalk Between Autophagy and the Ubiquitin-Proteasome System
- 1Faculty of Engineering and Natural Sciences, Sabancı University, Turkey
- 2EFSUN - Center of Excellence on Nano Diagnostics,Faculty of Engineering and Natural Sciences, Sabancı University, Turkey
- 3Sabanci University Nanotechnology Research and Application Center (SUNUM), Turkey
Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System
Nur Mehpare Kocaturk1 and Devrim Gozuacik1,2,3*
1Sabanci University, Faculty of Engineering and Natural Sciences, Molecular Biology, Genetics and Bioengineering Program, Istanbul, 34956, Turkey.
2Sabanci University, Center of Excellence for Functional Surfaces and Interfaces for Nano Diagnostics (EFSUN), Istanbul, 34956, Turkey.
3Sabanci University Nanotechnology and Application Center (SUNUM), Istanbul, 34956, Turkey.
Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular quality control and recycling mechanisms that are responsible for cellular homeostasis in eukaryotes. Ubiquitylation is utilized as a degradation signal by both systems, yet, different mechanisms are in play. The UPS is responsible for the degradation of short-lived proteins and soluble misfolded proteins whereas autophagy eliminates long-lived proteins, insoluble protein aggregates and even whole organelles (e.g., mitochondria, peroxisomes) and intracellular parasites (e.g., bacteria). Both the UPS and selective autophagy recognize their targets through their ubiquitin tags. In addition to an indirect connection between the two systems through ubiquitylated proteins, recent data indicate the presence of connections and reciprocal regulation mechanisms between these degradation pathways. In this review, we summarize these direct and indirect interactions and crosstalks between autophagy and the UPS, and their implications for cellular stress responses and homeostasis.
Keywords: Proteasome, Autophagy, homeostais, UPS, Ubiquitin, mitophagy, organelle homeostasis, protein quality control (PQC)
Received: 09 Jul 2018;
Accepted: 13 Sep 2018.
Edited by:Ioannis Nezis, University of Warwick, United Kingdom
Reviewed by:Viktor Zarsky, Faculty of Science, Charles University, Czechia
Sushil Devkota, University of California, San Diego, United States
Copyright: © 2018 Kocaturk and Gozuacik. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Devrim Gozuacik, Faculty of Engineering and Natural Sciences, Sabancı University, Istanbul, 34956, Turkey, email@example.com