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Perspectives in Zebrafish Research

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Front. Cell Dev. Biol. | doi: 10.3389/fcell.2018.00159

Is Alzheimer’s also a stem cell disease? – The zebrafish perspective

 Caghan Kizil1, 2* and Prabesh Bhattarai2
  • 1Forschungszentrum für Regenerative Therapien Dresden, Technische Universität Dresden, Germany
  • 2Deutsche Zentrum für Neurodegenerative Erkrankungen, Helmholtz-Gemeinschaft Deutscher Forschungszentren (HZ), Germany

Alzheimer’s disease (AD) is the most common neurodegenerative disease and is the leading form of dementia. AD entails chronic inflammation, impaired synaptic integrity and reduced neurogenesis. The clinical and molecular onsets of the disease do not temporally overlap and the initiation phase of the cellular changes might start with a complex causativeness between chronic inflammation, reduced neural stem cell plasticity and neurogenesis. Although the immune and neuronal aspects in AD are well studied, the neural stem cell-related features are far less investigated. An intriguing question is, therefore, whether a stem cell can ever be made proliferative and neurogenic during the prevalent AD in the brain. Recent findings affirm this hypothesis and thus a plausible way to circumvent the AD phenotypes could be to mobilize the endogenous stem cells by enhancing their proliferative and neurogenic capacity and also provide the newborn neurons the potential to survive and integrate into the existing circuitry. To address these questions, zebrafish offers unprecedented information and tools, which can be effectively translated into mammalian experimental systems.

Keywords: Zebrafish, Alzheimer ' s disease, Neural Stem / Progenitor Cells, Regeneration, Neurogenesis

Received: 30 Sep 2018; Accepted: 06 Nov 2018.

Edited by:

Eirini Trompouki, Max-Planck-Institut für Immunbiologie und Epigenetik, Germany

Reviewed by:

Steffen Scholpp, University of Exeter, United Kingdom
Felix Loosli, Karlsruher Institut für Technologie (KIT), Germany  

Copyright: © 2018 Kizil and Bhattarai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Caghan Kizil, Forschungszentrum für Regenerative Therapien Dresden, Technische Universität Dresden, Dresden, 01307, Lower Saxony, Germany, caghan.kizil@crt-dresden.de