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Front. Cell Dev. Biol. | doi: 10.3389/fcell.2019.00114

Transcriptional regulation of autophagy: mechanisms and diseases.

 Carmine Settembre1,  chiara di malta1* and laura cinque1
  • 1Telethon Institute Of Genetics And Medicine, Italy

Macro(Autophagy) is a catabolic process that relies on the cooperative function of two organelles: the lysosome and the autophagosome. The recent discovery of a transcriptional gene network that co-regulates the biogenesis and function of these two organelles, and the identification of transcription factors, miRNAs and epigenetic regulators of autophagy, demonstrated that autophagy is controlled by both transcriptional and post-transcriptional mechanisms. In this review article we discuss the nuclear events controlling autophagy, focusing particularly on the role of the MiT/TFE transcription factor family. In addition, we will discuss the evidence suggesting that the transcriptional regulation of autophagy might be targeted for the treatment of human genetic diseases.

Keywords: Autophagy, TFEB, Genetic diseases, nucleus, transcription, lysosomal storage disease

Received: 26 Feb 2019; Accepted: 05 Jun 2019.

Edited by:

Sovan Sarkar, University of Birmingham, United Kingdom

Reviewed by:

Cecilia Bucci, University of Salento, Italy
Marco Sandri, University of Padova, Italy  

Copyright: © 2019 Settembre, di malta and cinque. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. chiara di malta, Telethon Institute Of Genetics And Medicine, Naples, Italy, dimalta@tigem.it