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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell Dev. Biol. | doi: 10.3389/fcell.2019.00174

Breast tissue biology expands the possibilities for prevention of age-related breast cancers

  • 1Lawrence Berkeley National Laboratory, United States
  • 2Beckman Research Institute, City of Hope, United States
  • 3Irell & Manella Graduate School of Biological Sciences, City of Hope, United States
  • 4Breast Science Advocacy Core, University of California, San Francisco, United States
  • 5Independent researcher, United States
  • 6LIfe Science Division, Irell & Manella Graduate School of Biological Sciences, City of Hope, United States

Preventing breast cancer before it is able to form is an ideal way to stop breast cancer. However, there are limited existing options for prevention of breast cancer. Changes in the breast tissue resulting from the aging process contribute to breast cancer susceptibility and progression and may therefore provide promising targets for prevention. Here we describe new potential targets, immortalization and inflammaging, that may be useful for prevention of age-related breast cancers. We also summarize existing studies of warfarin and metformin, current drugs used for non-cancerous diseases, that also may be repurposed for breast cancer prevention.

Keywords: breast cancer, Chemoprevention, Aging, Warfarin, Metformin, microenvironment, mammary gland, Epithelial

Received: 03 May 2019; Accepted: 12 Aug 2019.

Copyright: © 2019 Fresques, Zirbes, Shalabi, Samson, Preto, Stampfer and LaBarge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Mark A. LaBarge, Beckman Research Institute, City of Hope, Pasadena, California, United States, mlabarge@coh.org