Original Research ARTICLE
Selective phosphorylation of Akt/Protein-kinase B isoforms in response to dietary cues
- 1BIOTEC, Technische Universität Dresden, Germany
- 2Deutsche Zentrum für Diabetesforschung (DZD), Germany
- 3Paul Langerhans Institute Dresden, German Center for Diabetes Research, Dresden University of Technology, Germany
A calorie-rich diet is one reason for the continuous spread of metabolic syndromes in western societies. Smart food design is one powerful tool to prevent metabolic stress, and the search for suitable bioactive additives is a continuous task. The nutrient-sensing insulin pathway is an evolutionary conserved mechanism that plays an important role in metabolism, growth and development. Recently, lipid cues capable to stimulate insulin signalling were identified. However, the mechanistic base of their activity remains obscure to date. We show that specific Akt/Protein-kinase B isoforms are responsive to different calorie-rich diets, and potentiate the activity of the cellular insulin cascade. Our data add a new dimension to existing models and position Drosophila as a powerful tool to study the relation between dietary lipid cues and the insulin induced cellular signal pathway.
Keywords: Drosophila, Sacharomyces cerevisae, Yeast lipids, AKT isoform, Akt phoshphorylation, high caloric diet, insulin signaling, PKB, Akt, Cystobasidium oligophagum, Microbe-host interaction, Axenic, yeast growth phase , Akt Ser505, Akt Thr342
Received: 26 Apr 2019;
Accepted: 06 Sep 2019.
Copyright: © 2019 Trautenberg, Prince, Maas, Honold, Grzybek and Brankatschk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Dr. Michal Grzybek, Deutsche Zentrum für Diabetesforschung (DZD), Oberschleissheim, 85764, Germany, email@example.com
Dr. Marko Brankatschk, BIOTEC, Technische Universität Dresden, Dresden, 01307, Lower Saxony, Germany, firstname.lastname@example.org