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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell Dev. Biol. | doi: 10.3389/fcell.2019.00211

The Hippo signaling pathway in cardiac development and diseases

  • 1Cardiovascular & Metabolic Disorders Program, Duke-NUS Medical School, Singapore
  • 2National Heart Centre Singapore, Singapore
  • 3Duke-NUS Medical School, Singapore

Heart disease continues to be the leading cause of morbidity and mortality worldwide. Cardiac malformation during development could lead to embryonic or postnatal death. However, matured heart tissue has a very limited regenerative capacity. Thus, loss of cardiomyocytes from injury or diseases in adults could lead to heart failure. The Hippo signaling pathway is a newly identified signaling cascade that modulates regenerative response by regulating cardiomyocyte proliferation in the embryonic heart, as well as in postnatal hearts after injury. In this review, we summarize recent findings highlighting the function and regulation of the Hippo signaling pathway in cardiac development and diseases.

Keywords: Hippo signaling, cardiac development, Hypertrophy, Ischemia - reperfusion, cardiomyoapthies

Received: 30 Jan 2019; Accepted: 12 Sep 2019.

Copyright: © 2019 Singh and Mia. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Manvendra K. Singh, Duke-NUS Medical School, Cardiovascular & Metabolic Disorders Program, Singapore, Singapore,