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Front. Cell Dev. Biol. | doi: 10.3389/fcell.2019.00302

Endolysosomal Ca 2+ signalling in cancer: The role of TPC2, from tumorigenesis to metastasis

  • 1Department of Pharmacology, University of Oxford, United Kingdom
  • 2Pharmaceutical Sciences Department, King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia

Ca2+ homeostasis is dysregulated in cancer cells and affects processes such as tumorigenesis, angiogenesis, autophagy, progression, and metastasis. Emerging evidence has suggested that endolysosomal cation channels sustain several cancer hallmarks involving proliferation, metastasis, and angiogenesis. Here, we investigate the role of TPC1-2, TRPML 1-3, and P2X4 in cancer, with a particular focus on the role of TPC2 in cancer development, melanoma, and other cancer types as well as its endogenous and exogenous modulators. It has become evident that TPC2 plays a role in cancer; however, the precise mechanisms underlying its exact role remain elusive. TPC2 is a potential candidate for cancer biomarkers and a druggable target for future cancer therapy.

Keywords: Endolysosomal, Calcium, Ca2+ signals, TPC2, Cancer

Received: 24 Sep 2019; Accepted: 08 Nov 2019.

Copyright: © 2019 Alharbi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Miss. Abeer F. Alharbi, University of Oxford, Department of Pharmacology, Oxford, United Kingdom, abeer.alharbi@pharm.ox.ac.uk