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Correction ARTICLE

Front. Cell Dev. Biol., 19 June 2020 | https://doi.org/10.3389/fcell.2020.00462

Corrigendum: Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway

  • 1College of Animal Science and Technology, Anhui Agricultural University, Hefei, China
  • 2Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China

A Corrigendum on
Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway

by Li, Y., Ding, H., Liu, L., Song, Y., Du, X., Feng, S., et al. (2020). Front. Cell Dev. Biol. 8:245. doi: 10.3389/fcell.2020.00245

In the original article, there was a mistake in Figures 7 and 8 as published. The word “Necueus” should be changed to “Nucleus.” We have also removed the red line in Figure 8.

FIGURE 7
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Figure 7. Effect of NEFA on the activation of p53. (A) The protein expression levels and (B) quantification of p53 in dairy cows heaptocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM). (C) The protein expression levels and (D) quantification of p53 in dairy cows heaptocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (E) The transcriptional activity of p53 in dairy cows hepatocytes treated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (F) The NEFA-induced translocation of p53 from the cytosol to the nucleus in dairy cows hepatocytes incubated without or with NEFA (2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). Hepatocytes were fixed, stained with a specific antibody against p53 (red fluorescence) and counterstained with Hoechst 33258 (blue fluorescence). All results were obtained from three independent experiments and are expressed as the mean ± SD. *p < 0.05 and **p < 0.01 vs. the control group.

FIGURE 8
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Figure 8. NEFA induce the inhibition of Nrf2 in dairy cow hepatocytes. (A) The protein expression levels and (B) quantification of Nrf2 in dairy cows heaptocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM). (C) The protein expression levels and (D) quantification of Nrf2 in dairy cows hepatocytes incubated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (E) The transcriptional activity of Nrf2 in dairy cows treated with different concentrations of NEFA (0, 0.3, 0.6, 1.2, or 2.4 mM) in the presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). (F) The NEFA-induced translocation of Nrf2 from the cytosol to the nucleus in dairy cows hepatocytes incubated without or with NEFA (2.4 mM) in the absence or presence of SP600125 (10 μM), PD98059 (10 μM), and NAC (10 mM). Hepatocytes were fixed, stained with a specific antibody against Nrf2 (red fluorescence) and counterstained with Hoechst 33258 (blue fluorescence). All results were obtained from three independent experiments and are expressed as the mean ± SD. *p < 0.05 and **p < 0.01 vs. the control group.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

Keywords: NEFA, apoptosis, mitochondria-mediated ROS-JNK/ERK signaling pathway, dairy cow, hepatocyte

Citation: Li Y, Ding H, Liu L, Song Y, Du X, Feng S, Wang X, Li X, Wang Z, Li X, Li J, Wu J and Liu G (2020) Corrigendum: Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway. Front. Cell Dev. Biol. 8:462. doi: 10.3389/fcell.2020.00462

Received: 04 May 2020; Accepted: 18 May 2020;
Published: 19 June 2020.

Approved by:

Frontiers Editorial Office, Frontiers Media SA, Switzerland

Copyright © 2020 Li, Ding, Liu, Song, Du, Feng, Wang, Li, Wang, Li, Li, Wu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Guowen Liu, liuguowen2008@163.com