%A Chen,Xiaona %A He,Yanhong %A Fu,Wenjun %A Sahebkar,Amirhossein %A Tan,Yuhui %A Xu,Suowen %A Li,Hong %D 2020 %J Frontiers in Cell and Developmental Biology %C %F %G English %K Atherosclerosis,endothelial dysfunction,smooth muscle cells,macrophage,epigenetic,histone deacetylation,HDAC inhibitors %Q %R 10.3389/fcell.2020.581015 %W %L %M %P %7 %8 2020-November-12 %9 Review %# %! Role of HDAC in atherosclerosis %* %< %T Histone Deacetylases (HDACs) and Atherosclerosis: A Mechanistic and Pharmacological Review %U https://www.frontiersin.org/articles/10.3389/fcell.2020.581015 %V 8 %0 JOURNAL ARTICLE %@ 2296-634X %X Atherosclerosis (AS), the most common underlying pathology for coronary artery disease, is a chronic inflammatory, proliferative disease in large- and medium-sized arteries. The vascular endothelium is important for maintaining vascular health. Endothelial dysfunction is a critical early event leading to AS, which is a major risk factor for stroke and myocardial infarction. Accumulating evidence has suggested the critical roles of histone deacetylases (HDACs) in regulating vascular cell homeostasis and AS. The purpose of this review is to present an updated view on the roles of HDACs (Class I, Class II, Class IV) and HDAC inhibitors in vascular dysfunction and AS. We also elaborate on the novel therapeutic targets and agents in atherosclerotic cardiovascular diseases.