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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Cell. Infect. Microbiol. | doi: 10.3389/fcimb.2018.00431

Molecular Mechanisms of Bartonella and Mammalian Erythrocyte Interactions: A Review

 Hongkuan Deng1*, Qiuxiang Pang1, Bosheng Zhao1 and  Muriel Vayssier-Taussat2
  • 1Shandong University of Technology, China
  • 2INRA Biologie moléculaire et immunologie parasitaires, France

Bartonellosis is caused by Bartonella species that are distributed worldwide with animal and public health impact varying according to Bartonella and host species, immunological characteristics, infection phase and geographical region. Bartonella is widely distributed in ruminants, cats, dogs, rodents and other mammals including humans. At least 13 species or subspecies of Bartonella are zoonotic and each species appears to be highly adapted to a limited number of reservoir animals in which it is often asymptomatic. Bartonella infection may lead to a variety of clinical manifestations such as cat scratch disease, endocarditis, bacillary angiomatosis and bacillary peliosis in humans. As described in the B.tribocorum-rat model, when Bartonella was seeded into the blood stream, they could escape immunity, adhered to and invaded mature erythrocytes within 2 days. Once inside, they replicated and persisted in the infected erythrocytes for several weeks. This review summarizes our current understanding of how Bartonella prevent phagocytosis and complement activation, what pathogenesis factors are involved in erythrocyte adhesion and invasion, and how Bartonella could replicate and persist in mammalian erythrocytes. Current advances in research will help us to decipher molecular mechanisms of interactions between Bartonella and mammalian erythrocytes and may help in the development of biological strategies for the prevention and control of bartonellosis.

Keywords: Bartonellosis, erythrocyte interations, adhesion and invasion, replicate and persist, pathogenesis factors

Received: 12 Sep 2018; Accepted: 30 Nov 2018.

Edited by:

Eric Ghigo, IHU Mediterranee Infection, France

Reviewed by:

Michael F. Minnick, The University of Montana, United States
Victoria A. Blaho, Sanford Burnham Prebys Medical Discovery Institute (SBP), United States  

Copyright: © 2018 Deng, Pang, Zhao and Vayssier-Taussat. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Hongkuan Deng, Shandong University of Technology, Zibo, China, hongkuandeng@gmail.com