%A He,Weihang %A Liu,Xiaoqiang %A Hu,Bing %A Li,Dongshui %A Chen,Luyao %A Li,Yu %A Tu,Yechao %A Xiong,Situ %A Wang,Gongxian %A Deng,Jun %A Fu,Bin %D 2022 %J Frontiers in Cellular and Infection Microbiology %C %F %G English %K SARS-CoV-2,COVID-19,ACE2,Acute Kidney Injury,tmprss2 %Q %R 10.3389/fcimb.2022.838213 %W %L %M %P %7 %8 2022-June-14 %9 Review %+ Jun Deng,Department of Urology, The First Affiliated Hospital of Nanchang University,China,12294738@frontiersin.org %+ Bin Fu,Department of Urology, The First Affiliated Hospital of Nanchang University,China,12294738@frontiersin.org %+ Bin Fu,Jiangxi Institute of Urology,China,12294738@frontiersin.org %# %! COVID-19 and acute kidney injury %* %< %T Mechanisms of SARS-CoV-2 Infection-Induced Kidney Injury: A Literature Review %U https://www.frontiersin.org/articles/10.3389/fcimb.2022.838213 %V 12 %0 JOURNAL ARTICLE %@ 2235-2988 %X The severe acute respiratory coronavirus 2 (SARS-CoV-2) has become a life-threatening pandemic. Clinical evidence suggests that kidney involvement is common and might lead to mild proteinuria and even advanced acute kidney injury (AKI). Moreover, AKI caused by coronavirus disease 2019 (COVID-19) has been reported in several countries and regions, resulting in high patient mortality. COVID-19‐induced kidney injury is affected by several factors including direct kidney injury mediated by the combination of virus and angiotensin-converting enzyme 2, immune response dysregulation, cytokine storm driven by SARS-CoV-2 infection, organ interactions, hypercoagulable state, and endothelial dysfunction. In this review, we summarized the mechanism of AKI caused by SARS-CoV-2 infection through literature search and analysis.