%A Espinoza-Derout,Jorge %A Shao,Xuesi M. %A Lao,Candice J. %A Hasan,Kamrul M. %A Rivera,Juan Carlos %A Jordan,Maria C. %A Echeverria,Valentina %A Roos,Kenneth P. %A Sinha-Hikim,Amiya P. %A Friedman,Theodore C. %D 2022 %J Frontiers in Cardiovascular Medicine %C %F %G English %K electronic cigarettes,Nicotine,Heart Failure,cardiovascular disease,Atherosclerosis %Q %R 10.3389/fcvm.2022.879726 %W %L %M %P %7 %8 2022-April-07 %9 Review %# %! Electronic Cigarette and Cardiovascular Diseases %* %< %T Electronic Cigarette Use and the Risk of Cardiovascular Diseases %U https://www.frontiersin.org/articles/10.3389/fcvm.2022.879726 %V 9 %0 JOURNAL ARTICLE %@ 2297-055X %X Electronic cigarettes or e-cigarettes are the most frequently used tobacco product among adolescents. Despite the widespread use of e-cigarettes and the known detrimental cardiac consequences of nicotine, the effects of e-cigarettes on the cardiovascular system are not well-known. Several in vitro and in vivo studies delineating the mechanisms of the impact of e-cigarettes on the cardiovascular system have been published. These include mechanisms associated with nicotine or other components of the aerosol or thermal degradation products of e-cigarettes. The increased hyperlipidemia, sympathetic dominance, endothelial dysfunction, DNA damage, and macrophage activation are prominent effects of e-cigarettes. Additionally, oxidative stress and inflammation are unifying mechanisms at many levels of the cardiovascular impairment induced by e-cigarette exposure. This review outlines the contribution of e-cigarettes in the development of cardiovascular diseases and their molecular underpinnings.