Abstract
A 46-year-old man suffered from acute type A aortic dissection (TAAD) and underwent total arch replacement using the frozen elephant trunk (FET) procedure. During follow-up, we noted back pain and found distal stent graft-induced new entry (dSINE) at the FET distal part by computed tomography. We performed additional extended thoracic endovascular aortic repair (TEVAR) for this pathology. The time between TAAD repair and TEVAR was 2 months. We investigated this complication by computational fluid dynamics analysis through pre- and post-dSINE. The results showed increased wall shear stress at the narrowed true lumen (TL) site, not at the FET site, indicating that prestenotic hydrodynamic load may affect dSINE occurrence.
Introduction
With the worldwide use of the frozen elephant trunk (FET) procedure, consideration of distal stent graft-induced new entry (dSINE), a major FET complication, has become essential (1). Herein, we investigated wall shear stress (WSS) using computational fluid dynamics (CFD) analysis before and after dSINE occurrence following acute type A aortic dissection (TAAD) repair using the FET procedure. We consider that true lumen (TL) stenosis with poor aortic remodelling contributes to dSINE occurrence.
Case report
A 46-year-old man with no previous cardiovascular risk factors or medical history suffered from acute type A aortic dissection and underwent total arch replacement using a 26-mm 4-branched prosthetic graft (J Graft: Japan Lifeline, Tokyo, Japan) by the FET procedure using a 27–90 mm Frozenix (Japan Lifeline, Tokyo, Japan). During follow-up, the man suffered from back pain and contrast-enhanced computed tomography (CT) revealed dSINE at the FET. We performed additional extended thoracic endovascular aortic repair (TEVAR) for this pathology. The time between TAAD repair and TEVAR was 2 months. The patient was discharged on postoperative day 4 without any complications.
We investigated dSINE hydrodynamically using CFD analysis as we had CT data before and after dSINE. Postoperative computed tomography angiography (CTA) after TAAD repair revealed poor aortic remodelling with severe TL stenosis (Figure 1A). CTA after dSINE continued to show poor aortic remodelling and residual TL stenosis (Figure 1B). CFD analysis revealed a marked increase in WSS coinciding with the TL stenosis site of the descending aorta (Supplementary Video 1), which was thought to have caused a pressure gradient before and after this stenotic site. This pressure gradient may have affected the repetitive stimulation between the fragile dissected septum and the FET, causing dSINE (Supplementary Video 2). CFD analysis after additional extended TEVAR showed a WSS decrease at the descending and downstream aorta (Figure 2).
Figure 1
Figure 2
Discussion
dSINE, a major FET complication, reportedly occurs up to 25% after 3 years (2). When a prosthesis harder than the fragile dissected aorta is inserted, dSINE has been reported even when a graft elephant trunk was used, the so-called (soft-graft)-induced new entry (3).
Herein, we focused on addressing the possible risk factor of postoperative narrowed TL by analyzing the CFD streamline. An increased WSS just before the blood passes through the stenosis site has been shown in blood flow simulations involving patients with coarctation of the aorta (4). Similarly in this case, CFD analysis 7 days after the FET procedure showed a marked increase in WSS in the TL stenosis proximal site. This was an aortic stenosis-like condition, and repetitive heartbeat stimulation and mechanical stress on the solid FET and vulnerable dissected aorta in the distal arch caused dSINE. Osswald et al. retrospectively investigated WSS in dSINE development using CFD. They reported that elevated WSS may lead to aortic wall weakening which may be considered a risk factor for the progression or development of new dissections sites (5). In their review of 5 cases, they found elevated WSS in the descending aorta, suggesting that residual TL stenosis after the FET procedure may affect dSINE development.
Conclusion
We investigated dSINE hydrodynamically using CFD analysis and considered that the increased WSS due to TL narrowing and the repetitive mechanical contacts between the FET and the dissected and weakened aortic septum could cause dSINE. Poor aortic remodelling with a narrow TL would be a risk factor for dSINE after the FET procedure and TEVAR for type B aortic dissection.
Statements
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.
Ethics statement
The studies involving humans were approved by Saiseikai Yokohamashi Tobu Hospital. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin. Written informed consent was obtained from the individual(s), and minor(s)' legal guardian/next of kin, for the publication of any potentially identifiable images or data included in this article.
Author contributions
YI: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing. YoM: Conceptualization, Data curation, Formal Analysis, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing. YuM: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing. TS: Writing – original draft, Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Acknowledgments
We thank Dr. Edward Barroga (http://orcid.org/0000-0002-8920-2607) for editing the manuscript.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fcvm.2024.1478430/full#supplementary-material
Supplementary Video 1Computational fluid dynamics (CFD) before dSINE revealed a marked increase in WSS coinciding with the site of true lumen (TL) stenosis of the descending aorta.
Supplementary Video 2CFD at dSINE onset also showed an increase in WSS at the site of TL stenosis of the descending aorta.
References
1.
CzernyMEggebrechtHRousseauHMourozPRJanosiRALescanMet alDistal stent graft-induced new entry after TEVAR or FET: insights into a new disease from EuREC. Ann Thorac Surg. (2020) 110:1494–500. 10.1016/j.athoracsur.2020.02.079
2.
KreibichMBünteDBergerTVötschARylskiBKrombholz-ReindlPet alDistal stent graft-induced new entries after the frozen elephant trunk procedure. Ann Thorac Surg. (2020) 110:1271–9. 10.1016/j.athoracsur.2020.02.017
3.
LorenzVMuzziLTommasinoGTucciENeriE. (S)INE: (soft-graft)-induced new entry tear after elephant trunk procedure. Interdiscip Cardiovasc Thorac Surg. (2023) 9(36):ivac283. 10.1093/icvts/ivac283
4.
FujisueJTakayamaYTonokiSTanakaH. Utility of computational fluid dynamics for prediction of efficacy of the surgical interventions for aortic coarctation in adults. TCVS Tech. (2023) 13:16–21. 10.1016/j.xjtc.2023.01.007
5.
OsswaldAWeymannATsagakisKZubarevichAThielmannMSchmackBet alFirst insights into the role of wall shear stress in the development of a distal stent graft induced new entry through computational fluid dynamics simulations. J Thorac Dis. (2923) 15:281–90. 10.21037/jtd-22-1206
Summary
Keywords
computational fluid dynamics, distal stent graft-induced new entry, wall shear stress, frozen elephant trunk, aortic remodelling
Citation
Iida Y, Marushita Y, Motohashi Y and Sato T (2024) Case Report: Increase in wall shear stress in a narrowed true lumen after type A aortic dissection repair analyzed by computed fluid dynamics. Front. Cardiovasc. Med. 11:1478430. doi: 10.3389/fcvm.2024.1478430
Received
09 August 2024
Accepted
21 October 2024
Published
07 November 2024
Volume
11 - 2024
Edited by
Grigorios Korosoglou, GRN Klinik Weinheim, Germany
Reviewed by
Anastasios Psyllas, MHW Germany, Germany
Danai Laohachewin, University Heart Center Freiburg, Germany
Updates
Copyright
© 2024 Iida, Marushita, Motohashi and Sato.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yasunori Iida hhttss1130@gmail.com
ORCID Yasunori Iida orcid.org/0000-0002-2182-3060 Yoichi Marushita orcid.org/0009-0008-9845-1657
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.