ORIGINAL RESEARCH article
Sec. Systems Endocrinology
Volume 3 - 2012 | https://doi.org/10.3389/fendo.2012.00029
Variability in the heritability of body mass index: a systematic review and meta-regression
- 1 Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Cambridge, UK
- 2 Department of Paediatrics, University of Cambridge, Cambridge, UK
Evidence for a major role of genetic factors in the determination of body mass index (BMI) comes from studies of related individuals. Despite consistent evidence for a heritable component of BMI, estimates of BMI heritability vary widely between studies and the reasons for this remain unclear. While some variation is natural due to differences between populations and settings, study design factors may also explain some of the heterogeneity. We performed a systematic review that identified 88 independent estimates of BMI heritability from twin studies (total 140,525 twins) and 27 estimates from family studies (42,968 family members). BMI heritability estimates from twin studies ranged from 0.47 to 0.90 (5th/50th/95th centiles: 0.58/0.75/0.87) and were generally higher than those from family studies (range: 0.24–0.81; 5th/50th/95th centiles: 0.25/0.46/0.68). Meta-regression of the results from twin studies showed that BMI heritability estimates were 0.07 (P = 0.001) higher in children than in adults; estimates increased with mean age among childhood studies (+0.012/year, P = 0.002), but decreased with mean age in adult studies (−0.002/year, P = 0.002). Heritability estimates derived from AE twin models (which assume no contribution of shared environment) were 0.12 higher than those from ACE models (P < 0.001), whilst lower estimates were associated with self reported versus DNA-based determination of zygosity (−0.04, P = 0.02), and with self reported versus measured BMI (−0.05, P = 0.03). Although the observed differences in heritability according to aspects of study design are relatively small, together, the above factors explained 47% of the heterogeneity in estimates of BMI heritability from twin studies. In summary, while some variation in BMI heritability is expected due to population-level differences, study design factors explained nearly half the heterogeneity reported in twin studies. The genetic contribution to BMI appears to vary with age and may have a greater influence during childhood than adult life.
Studies of twins and families have quantified the contribution of genetic variation to inter-individual differences in body mass index (BMI). In the last comprehensive review of BMI heritability, Maes et al. (1997) reported that the proportion of phenotypic variance (VP) that can be attributed to genetic factors (h2) ranged from 0.40 to 0.90 in twin studies and 0.20 to 0.50 in family studies, demonstrating the wide variation in the magnitude of BMI heritability observed both within and between these study designs (Maes et al., 1997). Genome-wide association studies (GWAS) have so far identified 32 loci robustly associated with adult BMI (Frayling et al., 2007; Loos et al., 2008; Thorleifsson et al., 2009; Willer et al., 2009; Speliotes et al., 2010). Despite highly statistically significant associations, these 32 loci account for less than 2% of the total VP in BMI. Sub-genome-wide significant variants may be able to explain a substantial portion of the unexplained genetic variance of complex traits. However, even when considering such variants, the variance explained remains lower than estimates of heritability (Yang et al., 2011) and much attention has been focused on finding the so-called “missing heritability” (Manolio et al., 2009).
Twin studies are used to quantify genetic and environmental contributions to variation in BMI by comparing intra-pair concordance between monozygotic (MZ) twins and dizygotic (DZ) twins. Assignment of zygosity (MZ or DZ) to twin pairs is achieved either using questionnaires or more accurate DNA-based methods. Twin studies model the VP to be the composite of up to four components: (A) additive genetic factors; (D) non-additive or dominant genetic factors; (C) shared environmental factors; and (E) non-shared environmental factors (Neale and Cardon, 1992; Rijsdijk and Sham, 2002). Heritability is usually reported as the proportion of overall VP that can be attributed to additive genetic factors (h2 = A/Vp), as dominant genetic factors (D) are confounded with shared environmental factors (C) and cannot be estimated in the same model. The “best estimate” of heritability is calculated from the statistically best fitting and most parsimonious combination of the three remaining variance components (A, C, and E), determined by sequentially removing components from the model and testing for deterioration in fit in structural equation modeling (Rijsdijk and Sham, 2002; Figure A1 in Appendix).
Quantitative genetic analysis in family studies also allows variance in BMI to be partitioned into genetic and environmental components. Estimates of familiality indicate to what extent members of the same family share traits (representing the A, D, and C components of VP combined) to infer an inherited component. Heritability estimates can be estimated by maximum likelihood variance decomposition (Almasy and Blangero, 1998) or by regressing offspring phenotype onto mean parental phenotype (Lawlor and Mishra, 2009). However, it should be noted that family studies cannot explain to what extent this familial similarity arises from genetic relatedness as opposed to shared environmental factors.
We aimed to identify papers that have estimated the heritability of BMI, and to identify and quantify by meta-regression the effects of demographic and methodological factors that contribute to the heterogeneity between estimates.
Materials and Methods
Papers that reported BMI heritability were identified on PubMed. A search was performed in February 2010 with the term “heritability,” combined with the MeSH term “body mass index,” limited to human studies reported in the English language, and this generated 209 papers. Titles and abstracts were assessed for their relevance; inclusion criteria were twin or family studies reporting a quantitative estimate for BMI heritability (h2) as a measure of additive genetic factors (N = 64 papers). Supplementary searches (for example, using the term “genetic contribution” rather than heritability) were performed together with cross-referencing to identify further studies that had not been captured by the original search. For papers duplicating estimates from the same populations, either the study reporting a secondary analysis or using a smaller subset of the dataset was excluded (N = 10). One study was excluded because it reported the heritability of maximal life-time BMI. To enable a quantitative meta-analysis, measures of uncertainty for the heritability estimates were required. For twin study papers not reporting SE or confidence intervals, heritability, and confidence intervals were calculated directly. This calculation was not possible if twin studies also did not report MZ/DZ correlations (N = 6), mean BMI by zygosity (N = 4), or SD of mean BMI by zygosity (N = 2). Family studies not reporting SE or confidence intervals for BMI heritability were also excluded (N = 6). In total, 31 papers reporting twin studies and 25 papers reporting family studies were eligible for inclusion (Figure A2 in Appendix); many of these papers reported estimates from more than one study.
Data Extraction and Classification
Estimates of BMI heritability as a measure of additive genetic components were extracted from each paper, where possible by independent subgroup based on sex, age group, ethnicity, or setting, the source study and, in twin studies, whether twins were raised apart or together. Information was also obtained on the location of the study, the study to which the twins or family members were recruited (where relevant) and the mean age, age range, and number of participants in each study. Twin studies were categorized according to: whether they were conducted in adults (>18 years) or children (≤18 years); the variance component model used to derive the best heritability estimates (ACE versus AE); the method used to assign zygosity (DNA or biological versus questionnaire); and whether BMI was calculated from objective measurements or self reported body size. Where studies had used mixed strategies to determine twin zygosity, for example if they DNA tested uncertain cases, they were categorized as using a DNA-based/biological strategy.
For studies that did not report measures of uncertainty around BMI heritability, heritability estimates, and their confidence intervals were re-calculated using OpenMx (Boker et al., 2011). Firstly, datasets were simulated based on the reported number of MZ and DZ twins in each study and the mean and SD of BMI in each class of twins. Structural equation modeling was then used to decompose the variance in BMI into additive genetic, shared environmental and unique environmental components based on intra-class correlations of BMI in MZ and DZ twin pairs. In studies that reported heritability from AE models, we also excluded the C component in our re-calculation. To make this analysis more robust, a bootstrapping approach was applied, whereby twin pairs were sampled 1,000 times for each heritability estimate. Re-calculated estimates were highly correlated with originally reported estimates (r = 0.91).
A meta-analysis of the reported or re-calculated estimates of heritability from each study was performed separately for twin and family studies using metan in Stata (Version 11.0). A random effects model was used which accounts for inter-study heterogeneity. Where possible, estimates from men and women were included separately in the twin study meta-analysis, and subgroup estimates by sex were calculated. In longitudinal studies, the baseline heritability or the estimate based on the measurement with largest number of twins was selected. To investigate potential explanations for heterogeneity in estimates across twin studies, random effects meta-regression analyses were conducted using the metareg (Sharp, 1998; Harbord and Steichen, 2004) command in Stata. In these analyses, weights are assigned according to the inverse of the total variance, comprising the individual study variance and the residual between study variance. The influence of sex, age, setting (populations of white compared with East Asian descent), publication year, sample size, choice of variance component model, method used to determine zygosity and method used to determine BMI were quantified. To test for effects of age on BMI heritability, twin study estimates from adults versus children were compared. Secondly, as we have observed biphasic patterns of age modification of genetic effects of FTO and MC4R on BMI and body weight (Hardy et al., 2010), a meta-regression of mean age (or, when this was not reported, the mid-point of the age range as a proxy) was performed in childhood and adulthood studies separately. A similar meta-regression was performed on family study estimates to test for any detectable effects of sample size, mean, or mid age of participants, publication year, and setting of the study (US or European versus East Asian).
The overall heterogeneity in BMI estimates explained by all significant factors was calculated as the proportion of the τ2 statistic, which measures between study variance (Thompson and Sharp, 1999), that is accounted for when including these covariates in a meta-regression model. This analysis was based on 70 heritability estimates which could be categorized into adulthood or childhood, AE or ACE models, biological or questionnaire-based zygosity determination and self report or objective BMI assessment.
A total of 88 independent estimates of BMI heritability from twin studies were identified from 31 papers (Stunkard et al., 1986, 1990; Hewitt et al., 1991; Korkeila et al., 1991; Neale and Cardon, 1992; Carmichael and McGue, 1995; Forbes et al., 1995; Harris et al., 1995; Herskind et al., 1996; Austin et al., 1997; Faith et al., 1999; Knoblauch et al., 1999; Narkiewicz et al., 1999; Pietilainen et al., 1999; Vinck et al., 1999; Baird et al., 2001; Poulsen et al., 2001; Schousboe et al., 2003, 2004; Nelson et al., 2006; Cornes et al., 2007; Hur, 2007; Ordonana et al., 2007; Silventoinen et al., 2007a,b; Souren et al., 2007; Hur et al., 2008; Liu et al., 2008; Wardle et al., 2008; Lajunen et al., 2009; Watson et al., 2010; Table 1; Figure A2 in Appendix). Reported estimates ranged from 0.47 to 0.90 (5th/50th/95th centiles: 0.58/0.75/0.87; Figure 1). In some papers, estimates were reported separately by sex, age subgroup, or geographical location. The overall sample represented a total of 171,227 twins and, allowing for a maximum potential overlap of 30,702 twins between the study samples, the pooled analysis comprised at least 140,525 independent twins. Between study heterogeneity across these estimates was substantial (I2 = 86.1%, P < 0.001; Figure 2).
Figure 1. Histogram showing the wide distribution of reported estimates of BMI heritability from twin studies (white bars) and family studies (gray bars).
Figure 2. Meta-analysis of BMI heritability estimates in twin studies. The forest plot shows the results of a random effects meta-analysis of 88 independent BMI heritability estimates from 31 papers.
In estimates from twin studies, there were similar overall heritability estimates for men (0.73; 95% CI: 0.71–0.76) and women (0.75; 95% CI: 0.73–0.77; Figure 2). This was confirmed by meta-regression, which found no effect of sex on the heritability estimate (Table 2). Nineteen of the 88 heritability estimates from twin studies were from children and adolescents (≤18 years), whilst 67 were in adulthood (two estimates were from populations that included participants spanning both childhood and adulthood). Meta-regression showed that, on average, BMI heritability in childhood was 0.07 higher (95% CI: 0.03–0.11, P = 0.001) than in adulthood (Table 2). Heritability estimates rose by 0.012/year throughout childhood (age ≤18 years; 95% CI: 0.005–0.019, P = 0.002), but decreased by −0.002/year in adulthood (95% CI: −0.004 to −0.001, P = 0.002; Figure 3). BMI heritability from East Asian populations (N = 5 populations) was 0.11 higher than that in populations of white European descent (95% CI: 0.03–0.18, P = 0.006), but this difference diminished after adjustment for age category (child versus adult studies; 0.06; 95% CI: −0.02–0.15, P = 0.125). The influence of birth cohort (year of birth of the twins) on heritability estimates was difficult to assess because some studies did not report the birth year of the participants and others reported large ranges, sometimes spanning multiple decades. More recent publication year was nominally associated with heritability in meta-regression analyses (0.003/+1 year, P = 0.055). However, this association was attenuated after adjustment for age category (child versus adult studies; P = 0.405).
Table 2. Results of meta-regression analyses to identify study-level demographic factors associated with reported BMI heritability estimates in twin studies.
Figure 3. Predicted BMI heritability by age. The dotted line represents predicted BMI heritability by age, modeled using piecewise linear splines with a knot point at age 18 to separate childhood and adulthood. The figure shows that the relative contribution of genetic factors to variation in BMI increases over childhood before declining during adult life. Each circle represents an individual estimate of BMI heritability, and the size of the circle is proportional to the inverse of the SE of the heritability estimate. Age is based on the mean age of the study sample, or the mid-point of the age range where this was not reported.
The number of twins included in each estimate of BMI heritability ranged from 66 to 8,142 individuals. In meta-regression models, sample size was unrelated to the BMI heritability estimates (P = 0.202, adjusted for age category). Fifteen of the best estimates of BMI heritability from twin studies were derived from the three-component ACE model, while the more parsimonious AE model was chosen as the best fitting model for 61 estimates. Eight estimates were derived from the ADE model and four estimates were obtained by direct comparisons of the within-pair correlations in monozygotic and dizygotic twins. Best estimates from AE variance component models were on average 0.12 higher than those from ACE models (P = 0.005), adjusted for age category (Table 3). When stratified into childhood or adult studies, this difference was of similar magnitude in children (0.11, 95% CI: 0.06–0.17, P = 0.001) and adults (0.13, 95% CI: 0.008–0.26, P = 0.038).
Table 3. Results of meta-regression analyses to identify study-level methodological factors associated with reported BMI heritability estimates in twin studies.
A total of 33 of the 88 twin study estimates used DNA or biological (blood typing or fingerprints) assignment of zygosity; the remaining 55 relied completely on questionnaire-based methods. Reliance on questionnaires to determine zygosity (compared with DNA or other biological methods) was associated with a 0.04 lower heritability estimate (P = 0.02), when adjusted for age category. Similarly, the heritability was on average 0.05 lower (P = 0.03) in studies that calculated BMI based on self reported height and weight (N = 59 estimates) compared with studies (N = 21 estimates) that objectively assessed BMI. Eight study estimates based on a combination of both methods were excluded from this meta-regression analysis.
Together, age category, type of variance component model, method of zygosity assignment and BMI measurement, explained 46.7% of the between study heterogeneity in BMI heritability.
A total of 28 independent estimates of BMI heritability were reported in 25 family study papers retrieved comprising 42,968 family members (Table 4; Longini et al., 1984; Hunt et al., 1989, 2002; Moll et al., 1991; Vogler et al., 1995; Bijkerk et al., 1999; Abney et al., 2001; Luke et al., 2001; Treuth et al., 2001; Arya et al., 2002; Coady et al., 2002; Jee et al., 2002; Henkin et al., 2003; Wu et al., 2003; Sale et al., 2005; Butte et al., 2006; Deng et al., 2006; Li et al., 2006; Bastarrachea et al., 2007; Bayoumi et al., 2007; Bogaert et al., 2008; de Oliveira et al., 2008; Patel et al., 2008; Friedlander et al., 2009; Zabaneh et al., 2009; Figure 1). Reported BMI heritability estimates ranged from 0.24 to 0.81 (5th/50th/95th centiles: 0.25/0.46/0.68), with substantial heterogeneity across estimates (I2 = 90.4%, P < 0.001; Figure 4). Meta-regression found no significant effect of sample size, age, setting, or publication year on heritability estimates in family studies (Table 5).
Figure 4. Meta-analysis of BMI heritability estimates in family studies. The forest plot shows the results of a random effects meta-analysis of 27 independent BMI heritability estimates from 25 papers.
Table 5. Results of meta-regression analyses to identify study-level demographic or methodological factors associated with reported BMI heritability estimates in family studies.
In a large meta-analysis of more than 140,525 twins and 42,968 family members, we observed that estimates of BMI heritability remain broadly in line with results from the earlier review by Maes et al. (1997). A substantial amount of the variation between estimates from twin studies could be explained by considering demographic and methodological factors. Estimates from twin studies suggest that the influence of genetic factors on BMI is relatively higher in children than in adults. In addition, we have identified and quantified the likely effects of three potential methodological biases in twin studies; these are the choice of final variance component model, and the use of subjective methods to assess both zygosity and BMI. Together these factors explained nearly half of the wide heterogeneity in BMI heritability estimates between studies.
Our finding of a biphasic change in the heritability of BMI with age, increasing with age in children and adolescents and decreasing with age adults, is entirely consistent with studies using specific genetic variants. Hardy et al. (2010) reported that the effect size of the rs9939609 single nucleotide polymorphism (SNP) in FTO on BMI rises until around age 20 years, before gradually attenuating into adulthood. We acknowledge limitations in our analysis including the lack of longitudinal information and reliance on the mean or mid-point of age used in meta-regression analyses. However, in support of our findings, the heritability of BMI has previously been shown to increase over childhood (Haworth et al., 2008) and decrease with age in adults (Korkeila et al., 1991) in twin studies with longitudinal data.
We found no difference in BMI heritability estimates between men and women. Individual studies have been inconsistent; some have reported higher BMI heritability estimates in women (Allison et al., 1994; Harris et al., 1995; Estourgie-van Burk et al., 2006), whilst others have reported the opposite finding (Stunkard et al., 1990; Korkeila et al., 1991). Other studies have found no difference or reported a pooled heritability estimate for men and women combined. BMI heritability does not differentiate fat and fat free mass heritability, and given the differences in body composition between sexes, it is plausible that genetic contributions to the variation in BMI may operate differently in men and women.
Hur et al. (2008) reported that heritability estimates for weight, height, and BMI were consistently higher in Caucasian compared with East Asian populations. However, in that study the observed differences were small and confidence intervals were overlapping. In this study, no significant difference was found in the magnitude of BMI heritability from European and East Asian settings after accounting for whether the studies were in childhood or adulthood; however there were only a few studies in East Asians.
The majority of studies reported estimates of BMI heritability from the more parsimonious AE variance component model, rather than from the more complete ACE model. Not surprisingly, heritability (variance attributed to the A component) was higher in studies reporting the AE model, presumably because the variance that would have been attributed to C is re-allocated to components A and E in these analyses. Silventoinen et al. (2010) reported that the C component was relevant to BMI variation only in children up to age 13 years old. However, we found that exclusion of the C component had a similar magnitude of effect on higher heritability estimates in both children and adults. While omission of the C component is statistically best fitting in some analyses, smaller twin studies are often underpowered to identify a significant contribution of this component (Visscher et al., 2008a). These findings suggest that it may be inappropriate to simply ignore any contribution relating to common environmental factors.
The twin study design relies on the accurate identification of MZ and DZ twin pairs. The “gold standard” method is by DNA typing of all twins but, before genotyping technologies became widespread and cost–effective, questionnaire-based methods were common and were used to generate more than half of the BMI heritability estimates that we identified. Such questionnaires are based on subjective assessment of physical resemblance and, although some have been validated against genetic and biological methods (Sarna et al., 1978; Ooki et al., 1993), any non-differential misclassification error would inflate the E component and reduce the additive genetic component. Similarly, non-differential errors in self reported height and weight to calculate BMI would also inflate the unique environment component. These findings are consistent with those of Macgregor et al. (2006), who showed that heritability estimates for self reported height were lower than for objectively measured height.
Heritability estimates from twin studies are considerably higher than estimates from family studies. Twin studies are generally thought to provide a more robust discrimination between environmental and genetic contributions due to the more precise estimation of shared genetic factors and the automatic matching for age, prenatal environment, and birth cohort. However, it is suggested that the twin study design overestimates heritability because of its over-reliance on critical assumptions (Kyvik, 2000). The most commonly highlighted assumption is that of equal common environments in identical and non-identical twin pairs. In reality, MZ twin pairs may share a common environment to a larger extent than DZ pairs, which would lead to an overestimation of heritability (Hettema et al., 1995; Guo, 2001). This can be overcome by studying twin pairs who were separated at birth (Stunkard et al., 1990), a natural experiment whereby individuals are genetically identical but environmentally different. However, such twins are rare and difficult to study, as adoption data is not easy to obtain. Family studies do not invoke some of the problems of the twin study design. For example, questions of equal environments and accurate zygosity recording are eliminated and singletons are more representative of the general population than twins (Estourgie-van Burk et al., 2006). However, the family study design does not permit the differentiation of familial similarity arising from genetics as opposed to shared environmental conditions. In addition, in family studies, parents and children are usually measured at very different ages, often across generations, and lack of consideration of age–genotype interactions will lead to under-estimation of heritability. This might explain why heritability estimates are generally lower in family studies despite the fact that they do not distinguish between genetic and shared environmental variance components.
A limitation of this study was the inability to distinguish effects of demographic and methodological factors from other correlated study characteristics. For example, studies on children are likely to be over-representative of individuals from more recent birth years, making it difficult to separate effects of age and era. Genetic factors may have been relatively more important before the onset of the obesogenic environment, but others have suggested that these conditions may amplify the effects of obesity susceptibility loci (Andreasen et al., 2008). Era effects were difficult to assess in this study and the separation of birth cohort and age effects on BMI heritability requires confirmation by longitudinal data from large twin cohort studies spanning wide eras.
It should be noted that the models used to calculate heritability are often based on the unlikely assumption that there is no synergistic interaction between genes. Although the study designs discussed here do not usually permit their determination because of confounding with effects of the common environment, non-additive genetic factors may also play an important role (Segal and Allison, 2002). Furthermore, gene–environment interaction is not accounted for in these studies, and any such contribution is allocated to the A component (Visscher et al., 2008b).
It is important to emphasize that there is no single true value for heritability, as the balance between genetic and environmental contributions will naturally vary with the environmental setting and genetic lineage. However, we now show that issues relating to study design also explain a substantial part of the differences in the reported estimates of BMI heritability. In family studies we were unable to explain any of the heterogeneity across estimates. However, it is likely that other unmeasured factors, for example more precise measurement of geographical and population-level environmental factors such as urban versus rural setting, recreational facilities, nutritional availability, affluence, and also cultural factors and ethnicity, might contribute to the remaining variability in BMI heritability estimates in both twin and family studies.
In conclusion, while many studies in the current GWAS era report estimates from heritability studies as a rationale to look for specific genetic factors for complex traits, it should be emphasized that “missing” heritability is difficult to quantify given the wide heterogeneity in these estimates due to both natural variation and differences in study design. Given the higher heritability estimates in childhood and adolescence, focusing on periods of growth and development to study the genetic etiology of obesity risk is justified.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The authors would like to thank all authors of the papers included in this study, as well as participants in the contributing studies. This work was supported by the Medical Research Council.
BMI, body mass index; DZ, dizygotic; MZ, monozygotic.
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Figure A1. Modeling heritability in twin studies. This diagram shows how twin studies can model variance components, based on the path diagram proposed by Neale and Cardon (1992). The lines adjoining variance components indicate the degree of correlation (r), shown for both monozygotic (MZ) and dizygotic (DZ) twins. Additive genetic variance (A) is 100% correlated for MZ twin pairs and 50% correlated for DZ twin pairs. Common environment is shared (C) 100% by both types of twin. E represents a unique environmental component, and hence there is no correlation. Statistical modeling allows phenotypic variance to be quantitatively decomposed into A, C, and E subcomponents (the ACE model). The estimate of A gives a measure of the heritability of the trait. In a more parsimonious AE model, the C component would be missing from this diagram.
Keywords: body mass index, twin study, family study, heritability
Citation: Elks CE, den Hoed M, Zhao JH, Sharp SJ, Wareham NJ, Loos RJF and Ong KK (2012) Variability in the heritability of body mass index: a systematic review and meta-regression. Front. Endocrin. 3:29. doi: 10.3389/fendo.2012.00029
Received: 20 October 2011;
Accepted: 07 February 2012;
Published online: 28 February 2012.
Edited by:David Meyre, McMaster University, Canada
Reviewed by:Claire M. A. Haworth, King’s College London, UK
Christian Dina, CNRS, France
Jane Wardle, University College London, UK
Copyright: © 2012 Elks, den Hoed, Zhao, Sharp, Wareham, Loos and Ong. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
*Correspondence: Ken K. Ong, Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital Box 285, Cambridge CB2 0QQ, UK. e-mail: email@example.com