%A Bandyopadhyay,Gautam K. %A Mahata,Sushil K. %D 2017 %J Frontiers in Endocrinology %C %F %G English %K Obesity,Insulin Resistance,Inflammation,chromogranin A knockout,Pancreastatin,Catestatin %Q %R 10.3389/fendo.2017.00020 %W %L %M %P %7 %8 2017-February-08 %9 Mini Review %+ Sushil K. Mahata,Department of Medicine, University of California San Diego,USA,smahata@ucsd.edu %+ Sushil K. Mahata,Department of Medicine, Metabolic Physiology and Ultrastructural Biology Laboratory, VA San Diego Healthcare System,USA,smahata@ucsd.edu %# %! Chromogranin A, obesity, and insulin action %* %< %T Chromogranin A Regulation of Obesity and Peripheral Insulin Sensitivity %U https://www.frontiersin.org/articles/10.3389/fendo.2017.00020 %V 8 %0 JOURNAL ARTICLE %@ 1664-2392 %X Chromogranin A (CgA) is a prohormone and granulogenic factor in endocrine and neuroendocrine tissues, as well as in neurons, and has a regulated secretory pathway. The intracellular functions of CgA include the initiation and regulation of dense-core granule biogenesis and sequestration of hormones in neuroendocrine cells. This protein is co-stored and co-released with secreted hormones. The extracellular functions of CgA include the generation of bioactive peptides, such as pancreastatin (PST), vasostatin, WE14, catestatin (CST), and serpinin. CgA knockout mice (Chga-KO) display: (i) hypertension with increased plasma catecholamines, (ii) obesity, (iii) improved hepatic insulin sensitivity, and (iv) muscle insulin resistance. These findings suggest that individual CgA-derived peptides may regulate different physiological functions. Indeed, additional studies have revealed that the pro-inflammatory PST influences insulin sensitivity and glucose tolerance, whereas CST alleviates adiposity and hypertension. This review will focus on the different metabolic roles of PST and CST peptides in insulin-sensitive and insulin-resistant models, and their potential use as therapeutic targets.