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Front. Endocrinol. | doi: 10.3389/fendo.2018.00211

Mitochondrial dynamics in type 2 diabetes and cancer

Michelle Williams1 and  M. Cecilia Caino1*
  • 1Department of Pharmacology, University of Colorado Denver School of Medicine, United States

Mitochondria are bioenergetic, biosynthetic, and signaling organelles that control various aspects of cellular and organism homeostasis. Quality control mechanisms are in place to ensure maximal mitochondrial function and metabolic homeostasis at the cellular level. Dysregulation of these pathways is a common theme in human disease. In this mini-review, we discuss how alterations of the mitochondrial network influences mitochondrial function, focusing on the molecular regulators of mitochondrial dynamics (organelle’s shape). We highlight similarities and critical differences in the mitochondrial network of cancer and type 2 diabetes, which may be relevant for treatment of these diseases.

Keywords: Mitochondria, Fission, Fusion, diabetes, Cancer

Received: 29 Jan 2018; Accepted: 16 Apr 2018.

Edited by:

Che-Pei Kung, School of Medicine, Washington University in St. Louis, United States

Reviewed by:

Eirini Lionaki, Foundation for Research and Technology Hellas, Greece
Dhanendra Tomar, Temple University, United States
Thibaud T. Renault, Institut für Biologie, Pflanzenphysiologie, Humboldt-Universität zu Berlin, Germany  

Copyright: © 2018 Williams and Caino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. M. Cecilia Caino, University of Colorado Denver School of Medicine, Department of Pharmacology, Aurora, 80045, Colorado, United States, cecilia.caino@ucdenver.edu