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This article is part of the Research Topic

Follicle-Stimulating Hormone: Beyond Fertility

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Front. Endocrinol. | doi: 10.3389/fendo.2019.00015

Modulation of gonadotropins activity by antibodies

 Elodie Kara1*, Laurence Dupuy1, Céline Bouillon1, 2, 3, 4, 5, Sophie Casteret1 and Marie-Christine Maurel1
  • 1Igyxos S.A, France
  • 2Centre Hospitalier Universitaire de Tours, France
  • 3UMR7247 Physiologie de la reproduction et des comportements (PRC), France
  • 4Université de Tours, France
  • 5Federal Institute of Education, Science and Technology of Ceara (IFCE), Brazil

Gonadotropins are essential for reproduction control in humans as well as in animals. They are widely used all over the world for ovarian stimulation in women, spermatogenesis stimulation in men, and ovulation induction and superovulation in animals. Despite the availability of many different preparations, all are made of the native hormones. Having different ligands with a wide activity range for a given receptor helps better understand its molecular and cellular signaling mechanisms as well as its physiological functions, and thus helps the development of more specific and adapted medicines. One way to control the gonadotropins' activity could be the use of modulating antibodies. Antibodies are powerful tools that were largely used to decipher gonadotropins actions and they have shown their utility as therapeutics in several other indications such as cancer. In this review, we summarize the inhibitory and potentiating antibodies to gonadotropins, and their potential therapeutic applications.

Keywords: potentiating antibodies, Inhibitory antibodies, Follicle-stimulating hormone, Luteinizing Hormone, Chorionic Gonadotropin, signaling

Received: 30 Nov 2018; Accepted: 10 Jan 2019.

Edited by:

Livio Casarini, University of Modena and Reggio Emilia, Italy

Reviewed by:

Marco Bonomi, Istituto Auxologico Italiano (IRCCS), Italy
Luca De Toni, University of Padova, Italy  

Copyright: © 2019 Kara, Dupuy, Bouillon, Casteret and Maurel. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: PhD. Elodie Kara, Igyxos S.A, Nouzilly, France, elodie.kara@igyxos.com