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Follicle-Stimulating Hormone: Beyond Fertility

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Front. Endocrinol. | doi: 10.3389/fendo.2019.00322

Clinical use of FSH in male infertility

  • 1Martin Luther University of Halle-Wittenberg, Germany

The established clinical indication for FSH use in male infertility is the treatment of patients with hypogonadotropic hypogonadism for stimulation of spermatogenesis that allows the induction of a clinical pregnancy in the female partner and finally the birth of a healthy child. Several clinical studies with urinary, purified and recombinant FSH preparations in combination with hCG have demonstrated the high treatment efficacy regarding these clinical endpoints. Shortcomings of this hormone therapy are the long duration of treatment, sometimes longer than two years, and the inconvenience of injections every second or third day. However, improvements of therapy might be expected with new hormonal treatment options already available for infertility treatment in the female. FSH use for treatment of patients with normogonadotropic idiopathic infertility and oligozoospermia is still considered experimental in most countries. Recent meta-analyses have shown that FSH can significantly increase pregnancy rates in the female partners of these patients, but the effect-size is relatively low. Therefore, predictive factors for treatment success have to be identified, including FSH pharmacogenetics, to select the right normogonadotropic patients with idiopathic infertility for FSH therapy.

Keywords: FSH, hMG, male infertility, Hypogonadotropic hypodonadism, Idiopathic male infertility

Received: 18 Mar 2019; Accepted: 02 May 2019.

Edited by:

Manuela Simoni, University of Modena and Reggio Emilia, Italy

Reviewed by:

Alberto Ferlin, University of Brescia, Italy
Sandro C. Esteves, Androfert, Andrology and Human Reproduction Clinic, Brazil  

Copyright: © 2019 Behre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Hermann M. Behre, Martin Luther University of Halle-Wittenberg, Halle, Germany,