- 1Dpt. Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, Spain
- 2Massey University, New Zealand
- 3Western Sydney University, Australia
The stress response in vertebrates is characterized by involving physiological regulatory systems and a number of organs, tissues and effector pathways in order to both respond to the stressor effects and overcome the situation and recover homeostasis. Although differences in specific mechanisms are encountered in different animal groups and even between interspecies and intraspecies, the stress response involves an endocrine activation in all groups of vertebrates. Since an increasing number of scientific works are currently published in this field, the idea of collecting and reviewing such advances originated the initiative of a Topic Collection on the Comparative Stress responses in Vertebrates. In the following set of papers, the readers will find out an interesting update of the latest work in the field of the endocrine responses to stress in vertebrates, from general approaches to specific contributions and methodological updates. Of course, it is not intended that this Topic collection be exhaustive or complete, as many untreated aspects could be added, and some vertebrate groups are not well represented into the collection, but this overview is anyway interesting to show what are some of the current working areas in this field.
Among the general approaches presented in this Topic collection, a novel contribution is the concept of stressotope by Joan C. Balasch and Lluis Tort, linking the adaptive set of responses of the animal to particular biotopes associated with specific conditioning factors involving the maximum overall stress responses across immune-neuroendocrine relevant physiological levels and scenarios, including the characterization of behavioural response.
In relation with this stressotope concept, the work by Javier Sánchez Vázquez and colleagues, deep into the relationship among factors regulating the circadian rhythms in animals particularly under stress situations, showing that not only a number of specific environmental factors are connected to circadian rhythms, but also that the proper oscillations of the environmental factors are significantly involved.
In another of the works in this Topic, Miguel Gómez-Boronat, Ester Isorna and co-workers, investigating in daily cycles, demonstrate that the misalignment of external cues such as day-night photocycles and feeding time may temporarily alter fish homeostasis, thus involving a stress situation for the animals.
Other contributions make relevant insights in the comparative approach of endocrine stress regulation in vertebrates. In the first one, Edward Narayan and Tayla Vanderneut provided invaluable insights into how wild koalas respond physiologically to environmental trauma and disease, a species not often represented in the scientific literature of comparative stress responses. In addition, this paper includes an applied aspect on how methods of care, husbandry, and treatment can be used to reduce the impacts of stressors with the ultimate aim of increasing the rehabilitation possibilities and future release of this species in the wild.
In another paper, Erik Hoglund, Oyvind Overli and Svante Winberg show the role of Tryptophan and the associated metabolic pathways in the regulation of serotonergic activity in the fish brain, a key mechanism intimately associated to stress and behavioural responses of animals. ). Numerous studies have shown that elevated dietary Trp has a suppressive effect on aggressive behaviour and post-stress plasma cortisol concentrations in vertebrates. These effects are believed to be mediated by the brain serotonergic system, even though mechanisms involved are not well understood.
Also regarding key components in the diet, the work by Marce Herrera, Juan M. Mancera and Benjamin Costas, have looked at the studies on stress attenuation in animals through diet or supplement components. Other than the development of new technologies to monitor and improve environmental conditions of farmed animals, particularly fish, beneficial additives in the daily meal have been included in order to mitigate the effects of husbandry stressors. Immunological, nutritional and metabolic changes have been assessed in these trials, always associated to endocrine regulation. The biochemical and physiological functionality of those feed additives may strongly affect the stress response and, even, such additives may act as neurotransmitters, hormone precursors, energy substrates or cofactors implying multi-systematic and multi-organic responses that modify the response to stress.
Laura Suárez-Bregua, Pedro Guerreiro and Josep Rotllant focused their approach in a less studied area in lower vertebrates as the endocrine relationship between glucocorticoid metabolism and the parathyroid hormone family peptides. The paper deeps into the response driven by these hormones and other key regulators of mineral homeostasis in connection with bone remodelling processes, which involves important consequences in terms of harmonic growth and skeletal deformities.
A more specific comparative work on the stress and endocrine responses is presented by a group of researchers from Greece, Norway and The Netherlands. Thus, Athanasios Samaras, Marnix Gorissen and colleagues focus on the differential responses between two close warm water marine aquacultured species, sea bass and sea bream. In this paper, they show how significant can be the species-specific molecular and neuro-regional differences between two similar species sharing many environmental and geographical conditions. This points out how important can be the variability of specific mechanisms between species, even from close-related groups, though sharing the basic patterns of molecular and endocrine molecules and pathways.
Finally, regarding key methodological contributions, the paper by Johan Aerts rises the importance of the methodological aspects associated to the molecules currently chosen to define a stressed status. He demonstrates that it is pivotal to know the involved regulatory molecules and to understand how these molecules are synthesized, regulated and excreted, together with how these molecules grasp their actions on a plethora of biological processes in many organs and tissues.
Collectively, the Topic highlights current research areas and future directions in the dynamic field of vertebrate stress endocrinology. Beyond theoretical knowledge, the field of research provides powerful tools to enable researchers to make objective assessments of the physiological state of animals, to understand how animals respond to environmental change and human interventions. The applications of the Topic extends to wildlife and production animals to boost animal management, health and welfare programs.
Keywords: Editorial, stress, responses, endocrine, Vertebrates
Received: 03 Sep 2019;
Accepted: 06 Sep 2019.
Copyright: © 2019 Tort, Cockrem and Narayan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Prof. Lluis Tort, Autonomous University of Barcelona, Dpt. Cell Biology, Physiology and Immunology, Barcelona, 08193, Barcelona, Spain, Lluis.Tort@uab.es