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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00699

Comparative evaluation of biomarkers of inflammation among Indian women with Polycystic Ovary Syndrome (PCOS) consuming vegetarian versus non-vegetarian diet

 Mohd A. Ganie1*, Tajali Sahar1, Aafia Rashid1,  Ishfaq Wani1, Sobia Nisar2,  Thozhukat Sathyapalan3, Vishnubhalta Sreenivas4,  Lakshmy Ram4, Tabasum Parvez1 and Ishaq Geer5
  • 1Sher-I-Kashmir Institute of Medical Sciences, India
  • 2Government Medical College (GMC), India
  • 3University of Hull, United Kingdom
  • 4All India Institute of Medical Sciences, India
  • 5University of Kashmir, India

Background: Sub-inflammation and insulin resistance characterizes women with PCOS. Data on dietary modulation of inflammation among PCOS women is scant, particularly from Indian subcontinent.
Methods: This observational case-control study enrolled women with PCOS diagnosed as per the Rotterdam 2003 criteria and apparently healthy, age and BMI matched women from two populations following different dietary practices (vegetarian from New-Delhi; n=82 PCOS and n=179 healthy and non-vegetarian from Srinagar; n=62 PCOS and n=141 healthy women). Using a uniform methodology, a detailed clinical, biochemical, hormonal and inflammatory marker assessment was undertaken.
Results: The mean age of the overall cohort was 26.23±4.59years with a mean BMI of 24.39±3.72kg/m2. Overall pro-inflammatory markers (TNF-α, IL-6, IL-1β, hs-CRP and serum resistin) were significantly higher (p<0.05) and anti-inflammatory markers (IL-10 and adiponectin) were lower among women with PCOS than healthy subjects. On comparing vegetarian women with non-vegetarians counterparts, higher daily calorie intake (1895.46± 258.19 vs. 1860.13±323.96 Kcal) with a higher protein and fat and lower carbohydrate intake was recorded in the latter, although the percent energy derived from carbohydrates was higher among vegetarians. Clinical, biochemical and hormonal parameters were comparable among the groups except mFG score, total serum testosterone and serum lipid levels which were higher among non-vegetarian women as compared to their vegetarian counterparts from both categories (PCOS and healthy). Interestingly, vegetarian women with PCOS and healthy women had higher serum pro-inflammatory and lower anti-inflammatory markers compared to their non-vegetarian counterparts.
Conclusion: We conclude that PCOS women consuming Indian vegetarian diet have higher pro-inflammatory and lower anti-inflammatory marker levels than their age and BMI matched healthy non-vegetarian counterparts. This interesting observation can be attributed to the dietary composition, among other factors and needs confirmation from well-designed randomized studies on a larger cohort.
Clinical Trial Registration: The study was registered with CTRI database under registration number CTRI/2013/09/003996

Keywords: Inflammation, Diet, pcos, Hs-CRP, Insulin Resistance, Testosterone, Adiponectin

Received: 24 Jun 2019; Accepted: 26 Sep 2019.

Copyright: © 2019 Ganie, Sahar, Rashid, Wani, Nisar, Sathyapalan, Sreenivas, Ram, Parvez and Geer. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Mohd A. Ganie, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, India, ashraf.endo@gmail.com