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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00748

Possible mechanisms for maintenance and regression of corpus luteum through the ubiquitin-proteasome and autophagy system regulated by transcriptional factors

  • 1Institute of Genetics and Animal Breeding (PAS), Poland
  • 2Polish Academy of Sciences, Poland
  • 3Indian Veterinary Research Institute (IVRI), India
  • 4Graduate School of Frontier Biosciences, Osaka University, Japan
  • 5Institute of Animal Reproduction and Food Research (PAN), Poland

The corpus luteum (CL) is an important tissue of the female reproductive process which is established through ovulation of the mature follicle. Pulsatile release of prostaglandin F2α from the uterus leads to the regression of luteal cells and restarts the estrous cycle in most nonprimate species. The rapid functional regression of the CL, which coincides with decrease of progesterone production, is followed by its structural regression. Although we now have a better understanding of how the CL is triggered to undergo programmed cell death, the precise mechanisms governing CL protein degradation in a very short period of luteolysis remains unknown. The ubiquitin-proteasome pathway (UPP) maintains tissue homeostasis in the face of both internal and external stressors. The UPP also controls physiological processes in many gonadal cells. Emerging evidence suggests that UPP dysfunction is involved in male and female reproductive tract dysfunction. There are also a number of mechanisms involved in the degradation of cellular components including autophagy. Autophagy, which is activated when cells are exposed to different types of stressors such as hypoxia, starvation, and oxidative stress. While emerging evidence points to an important role for the UPP and autophagy in the CL, the key underlying transcriptional mechanisms have not been well documented. In this review, we propose how CL regression may be governed by the ubiquitin-proteasome and autophagy pathways. We will further consider potential transcription factors which may regulate these events in the CL.

Keywords: Corpus luteum (CL), ubiquitin-proteasome, Autophagy, Transcription Factors, steroidogenesis

Received: 29 Apr 2019; Accepted: 16 Oct 2019.

Copyright: © 2019 Teeli, Leszczynski, Krishnaswamy, Ogawa, Tsuchiya, Śmiech, Skarzynski and Taniguchi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Hiroaki Taniguchi, Polish Academy of Sciences, Warsaw, Poland, hiroataniguchi@hotmail.com