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Case Report ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Endocrinol. | doi: 10.3389/fendo.2019.00810

A Rare Aldosterone-producing Adenoma Detected by 68Ga-pentixafor PET-CT: a Case Report and Literature Review.

 Yunying Cui1, Yushi Zhang1, Jie Ding1, Huiping Wang1, Xiaoshen Ma1, Ou Wang1, Xiaoyan Chang1, hao Sun1, li Huo1* and  anli Tong1*
  • 1Peking Union Medical College Hospital (CAMS), China

Context: Primary aldosteronism represents an important and common cause of hypertension and is characterized by autonomous aldosterone secretion that results in severe hypertension and hypokalemia. Nonetheless, its manifestations are atypical in some cases, which renders its diagnosis difficult.
Case Description: Presented in this report is a Chinese female patient with blood pressure in the high-normal range, and her parathyroid hormone was significantly elevated. Elevated plasma aldosterone concentration plus suppressed plasma rennin activity was suggestive of primary aldosteronism. 68Ga-pentixafor positron emission tomography/computed tomography revealed an aldosterone-producing adenoma, which was globally the second of its kind ever reported so far. Moreover, the tumor was located in an extremely rare area.
Conclusions: Patients with primary aldosteronism may present with normal or high-normal blood pressure and a significantly elevated parathyroid hormone. 68Ga-pentixafor PET/CT is potentially a helpful tool for the noninvasive characterization of patients with primary aldosteronism.

Keywords: Aldosterone-producing adenomas, Blood Pressure, Parathyroid Hormone, Rare area, 68Ga-pentixafor PET-CT

Received: 29 Sep 2019; Accepted: 05 Nov 2019.

Copyright: © 2019 Cui, Zhang, Ding, Wang, Ma, Wang, Chang, Sun, Huo and Tong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Mx. li Huo, Peking Union Medical College Hospital (CAMS), Beijing, China, Huoli@pumch.cn
Mx. anli Tong, Peking Union Medical College Hospital (CAMS), Beijing, China, tonganli@hotmail.com