In the original article, there were mistakes in Figure 2A, Figure 6A, and Figure 7A as published. The immunofluorescence and immunohistochemistry images in the Sham group (Figure 2A) and RAPA groups in Figure 6A and Figure 7A, respectively, were erroneously used. The corrected Figures appear below.
FIGURE 2
FGF10 protects against I/R induced apoptosis in RTCs. (A) Representative sections of nuclear DNA fragmentation staining were performed using TUNEL in different groups at 24, 48, and 72 h, respectively, after reperfusion. Scale bars = 50 µM. (B) Quantitative analysis of the number of TUNEL-positive RTCs. Data are presented as the mean ± SD (n = 5). ∗p < 0.05, ∗∗∗p < 0.001. The percentage of positive cells was analyzed with 5 individual magnification × 400 fields per group.
FIGURE 6
FGF10 increases the expression of SQSTM1 and p-mTOR in I/R rats. (A) IHC staining was performed at 2 days after reperfusion for SQSTM1 in kidney tissues from indicated animal groups. Scale bars = 50 µm. (B) The expression of SQSTM1, p-mTOR and mTOR were detected by western blotting (mean ± SEM; n = 5). β-actin was used as control. ∗p < 0.05, ∗∗∗p < 0.001. (C,D) Optical density analysis for SQSTM1 and p-mTOR, which were normalized to β-actin and mTOR, respectively.
FIGURE 7
FGF10 inhibits the release of nuclear HMGB1 to the serum and regulates the TLR mRNA expression. (A) Immunofluorescence staining of HMGB1 at 2 days after reperfusion. Nuclei were labeled with DAPI (blue). Scale bars = 50 m. (B,C) Protein expression of HMGB1 in the nuclear fraction of renal tissues by Western blot and optical density analysis with β-actin as loading control (mean ± SEM; n = 5). ∗∗p < 0.01, ∗∗∗p < 0.001. (D) Level of serum HMGB1 was determined by ELISA (mean ± SEM; n = 5). ∗p < 0.05, ∗∗p < 0.01. (E,F) Expression of Tlr2 and Tlr4 mRNA in the kidney were examined by RT-qPCR and normalized to Gapdh. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.
The authors deeply apologize for these errors and state that these corrections do not change the scientific conclusions of the article in any way. The original article has been updated.
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Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
FGF10, ischemia-reperfusion (I/R), acute kidney injury, autophagy, inflammation, HMGB1
Citation
Tan X, Zhu H, Tao Q, Guo L, Jiang T, Xu L, Yang R, Wei X, Wu J, Li X and Zhang J-S (2021) Corrigendum: FGF10 Protects Against Renal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammatory Signaling. Front. Genet. 12:731406. doi: 10.3389/fgene.2021.731406
Received
27 June 2021
Accepted
20 October 2021
Published
12 November 2021
Volume
12 - 2021
Edited and reviewed by
Saverio Bellusci, University of Giessen, Germany
Updates
Copyright
© 2021 Tan, Zhu, Tao, Guo, Jiang, Xu, Yang, Wei, Wu, Li and Zhang.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xiaokun Li, profxiaokunli@163.com; Jin-San Zhang, Zhang_jinsan@163.com
This article was submitted to Stem Cell Research, a section of the journal Frontiers in Genetics
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.