Impact Factor 6.429

The 5th most cited journal in Immunology

Editorial ARTICLE

Front. Immunol., 06 February 2014 | https://doi.org/10.3389/fimmu.2014.00042

The nature of activatory and tolerogenic dendritic cell-derived signal 2

  • 1Department of Biotechnology and Bioscience, University of Milano-Bicocca, Milan, Italy
  • 2Institute of Virology and Immunobiology, University of Wuerzburg, Wuerzburg, Germany

Dendritic cells (DCs) were first described by Steinman and Cohn in 1973 (1) as cells provided of efficient antigen-presenting capacity. Steinmann received the Nobel Prize in 2011 for having revealed the pivotal role of DCs in linking innate and adaptive immunity and initiating antigen-specific immunity (2). The work conducted by Steinman was also instrumental in determining the role of DCs not only in activating adaptive immunity but also in controlling adaptive anti-self reactions by inducing and maintaining self-tolerance both at central and peripheral level (3).

Dendritic cells are highly heterogeneous. Two major classes of DCs have been described: classical or conventional and plasmacytoid DCs (pDCs). Classical DCs are cells of myeloid origin capable of efficiently capturing microbial antigens, and, after homing to lymph nodes and antigen processing, present these antigens to prime naive T cells. Diversely, pDCs are poorly phagocytic but recognize viruses very well. Upon encounter of microbial stimuli, they also differentiate into efficient antigen-presenting cells and express high levels of type I interferons (IFNs) (4). Based on tissue localization, transcription factor, and surface markers expression, classical DCs have been subdivided in a continuously growing number of subtypes (5, 6). Subsets expressing CD4/CD11b or CD8α/CD103 resides in secondary lymphoid organs; under healthy conditions lymph nodes contain additional subsets of partially matured steady state migratory DCs that transport self-antigens into lymph nodes for tolerance induction (710).

The DC capacity of inducing both immunity and tolerance may seem a contradictory aspect of DC biology, nevertheless the acquisition of these two different properties may depend on stimuli DC are exposed to or may be a specific feature of different DC subsets.

Dendritic cells sense the presence of exogenous microbial signals through germline-encoded pattern-recognition receptors (PRRs), which recognize molecular patterns expressed by various microorganisms or endogenous danger signals. The consequences of the activation of these receptors on DCs have been implicated in the acquisition of the immunogenic functions characterized by the increase of antigen presentation and costimulation as well as the release of proinflammatory cytokines. The attainment of the tolerogenic function by DCs seems instead to be more linked to the exposure to endogenous factors sensed in peripheral tissues under steady state conditions.

In the present Research topic, contributing articles describe a number of aspects determining the tolerogenic or immunogenic functions of DCs. In particular, the themes that will be discussed concern the role of DCs in controlling the threshold of activation of T cells; the role of the diverse costimulatory molecules, either secreted by DC subsets or expressed on the cell surface, in determining the DC immunogenic or tolerogenic functions; the role of endogenous or exogenous stimuli in influencing the DC functional state; some specific roles of DCs in preventing particular organ autoimmunity and, finally, possible therapeutic potentials of immunogenic or tolerogenic DCs.

Understanding the mechanisms that regulate the functional properties of DCs will allow exploiting these cells in new effective therapeutic strategies, including cancer immunotherapy and control of autoimmunity, to improve intervention outcomes. Understanding DC biology and their responses to activating stimuli will also help the identification of novel adjuvants to be used in new vaccine formulations.

References

1. Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med (1973) 137:1142–62. doi:10.1084/jem.137.5.1142

CrossRef Full Text

2. Steinman RM. Decisions about dendritic cells: past, present, and future. Annu Rev Immunol (2012) 30:1–22. doi:10.1146/annurev-immunol-100311-102839

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

3. Steinman RM, Nussenzweig MC. Avoiding horror autotoxicus: the importance of dendritic cells in peripheral T cell tolerance. Proc Natl Acad Sci U S A (2002) 99:351–8. doi:10.1073/pnas.231606698

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

4. Swiecki M, Colonna M. Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance. Immunol Rev (2010) 234:142–62. doi:10.1111/j.0105-2896.2009.00881.x

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

5. Satpathy AT, Wu X, Albring JC, Murphy KM. Re(de)fining the dendritic cell lineage. Nat Immunol (2012) 13:1145–54. doi:10.1038/ni.2467

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

6. Merad M, Sathe P, Helft J, Miller J, Mortha A. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol (2013) 31:563–604. doi:10.1146/annurev-immunol-020711-074950

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

7. Lutz MB, Schuler G. Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity? Trends Immunol (2002) 23:445–9. doi:10.1016/S1471-4906(02)02281-0

CrossRef Full Text

8. Lutz MB, Dohler A, Azukizawa H. Revisiting the tolerogenicity of epidermal Langerhans cells. Immunol Cell Biol (2010) 88:381–6. doi:10.1038/icb.2010.17

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

9. Vitali C, Mingozzi F, Broggi A, Barresi S, Zolezzi F, Bayry J, et al. Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells. Blood (2012) 120:1237–45. doi:10.1182/blood-2011-09-379776

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

10. Idoyaga J, Fiorese C, Zbytnuik L, Lubkin A, Miller J, Malissen B, et al. Specialized role of migratory dendritic cells in peripheral tolerance induction. J Clin Invest (2013) 123:844–54. doi:10.1172/JCI65260

Pubmed Abstract | Pubmed Full Text | CrossRef Full Text

Keywords: dendritic cells, T cell priming, tolerance, costimulatory molecules, danger signals, regulatory T cells

Citation: Granucci F, Lutz MB and Zanoni I (2014) The nature of activatory and tolerogenic dendritic cell-derived signal 2. Front. Immunol. 5:42. doi: 10.3389/fimmu.2014.00042

Received: 24 January 2014; Accepted: 24 January 2014;
Published online: 06 February 2014.

Edited and Reviewed by: Christian Kurts, Friedrich Wilhelms-Universität Bonn, Germany

Copyright: © 2014 Granucci, Lutz and Zanoni. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: francesca.granucci@unimib.it