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Front. Immunol. | doi: 10.3389/fimmu.2017.01674

Influence of microbiota on intestinal immune system in ulcerative colitis and its intervention

 Sailong Zhang1*, Shu-Na Wang1 and Chao-Yu Miao1
  • 1Second Military Medical University, China

Ulcerative colitis (UC) is an inflammatory bowel disease with chronic and recurrent characteristics caused by multiple reasons. Although the pathogenic factors have not been clarified yet, recent studies have demonstrated that intestinal microbiota plays an major role in UC, especially in the immune system. This review focuses on the description of several major microbiota communities that affect UC and their interactions with the host. In this review, eight kinds of microbiota which are highly related to IBD, including Faecalibacterium prausnitziib, Clostridium clusters IV and XIVa, Bacteroides, Roseburia species, Eubacterium rectale, Escherichia coli, Fusobacterium and Candida albicans are demonstrated on the changes in amount and roles in the onset and progression of IBD. In addition, potential therapeutic targets for UC involved in the regulation of microbiota, including NLRPs, VDR as well as secreted proteins, are discussed in this review.

Keywords: intestinal microbiota, Host immune response, ulcerative colitis, Epithelial Cells, therapeutic targets

Received: 07 Oct 2017; Accepted: 14 Nov 2017.

Edited by:

Kai Fang, University of California, Los Angeles, United States

Reviewed by:

Adam M. Reitzel, University of North Carolina at Charlotte, United States
Ka Man Law, University of California, Los Angeles, United States  

Copyright: © 2017 Zhang, Wang and Miao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Sailong Zhang, Second Military Medical University, Shanghai, China, sailongzhang@126.com