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Front. Immunol. | doi: 10.3389/fimmu.2018.00005

Nutrients Mediate Intestinal Bacteria-mucosal Immune Crosstalk

Pingting Guo1,  Jie Zhang1, Ting He1 and  Xi Ma1*
  • 1China Agricultural University, China

The intestine is the shared site of nutrient digestion, microbiota colonization and immune cell location and this geographic proximity contributes to a large extent to their interaction. The onset and development of a great many diseases such as IBD and metabolic syndrome will be caused due to the imbalance of body immune. As a competent assistant, the intestinal bacteria is also critical in disease prevention and control. Moreover, the gut commensal bacteria are essential for development and normal operation of immune system and the pathogens are also closely bound up with physiological disorders and diseases mediated by immune imbalance. Understanding how our diet and nutrient affect bacterial composition and dynamic function, and the innate and adaptive status of our immune system, represents not only a research need but also an opportunity or challenge of improving health. Herein, this review focuses on the recent discoveries about intestinal bacteria-immune crosstalk and nutritional regulation on their interplay. With an aim to provide novel insights that will aid understanding their interactions.

Keywords: Nutrients, Bacteria, mucosal immunity, intestine, crosstalk

Received: 04 Oct 2017; Accepted: 03 Jan 2018.

Edited by:

Kuldeep Dhama, Indian Veterinary Research Institute, India

Reviewed by:

Sunil Joshi, Old Dominion University, United States
Vincenzo Tufarelli, Università degli studi di Bari Aldo Moro, Italy
Arun Chaudhury, GIM Foundation, United States  

Copyright: © 2018 Guo, Zhang, He and Ma. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Xi Ma, China Agricultural University, Beijing, China,