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Front. Immunol. | doi: 10.3389/fimmu.2018.00350

Mechanisms of tolerance induction by dendritic cells in vivo

  • 1Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Japan

Dendritic cells (DCs) are a heterogeneous population playing a pivotal role in immune responses and tolerance. DCs promote immune tolerance by participating in the negative selection of autoreactive T cells in the thymus. Furthermore, to eliminate autoreactive T cells that have escaped thymic deletion, DCs also induce immune tolerance in the periphery through various mechanisms. Breakdown of these functions leads to autoimmune diseases. Moreover, DCs play a critical role in maintenance of homeostasis in body organs, especially the skin and intestine. In this review, we focus on recent developments in our understanding of the mechanisms of tolerance induction by DCs in the body.

Keywords: Dendritic Cells, Immune Tolerance, regulatory T cells, Thymus, development, Skin, Intestinal Mucosa

Received: 08 Oct 2017; Accepted: 07 Feb 2018.

Edited by:

John Isaacs, Newcastle University, United Kingdom

Reviewed by:

Raymond J. Steptoe, The University of Queensland, Australia
Hans Acha-Orbea, University of Lausanne, Switzerland  

Copyright: © 2018 Hasegawa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Hitoshi Hasegawa, Ehime University Graduate School of Medicine, Department of Hematology, Clinical Immunology and Infectious Diseases, Shitsukawa, Toho City, 791-0295, Ehime, Japan, hitoshih@m.ehime-u.ac.jp