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Front. Immunol. | doi: 10.3389/fimmu.2018.00399

Purinergic regulation of neutrophil function

  • 1The Affiliated Hospital, Jiangsu University, China

Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through activation of P2 receptors, whereas adenosine mostly functions as an anti-inflammatory molecule through activation of P1 receptors. Neutrophils are the most abundant immune cells in circulation and have emerged as an important component in orchestrating a complex series of events during inflammation. However, because of the destructive nature of neutrophil-derived inflammatory agents, neutrophil activation is fine-tuned, and purinergic signaling is intimately involved in this process. Indeed, shifting the balance between P2 and P1 signaling is critical for neutrophils to appropriately exert their immunologic activity. Here, we review the role of purinergic signaling in regulating neutrophil function, and discuss the potential of targeting purinergic signaling for the treatment of neutrophil-associated infectious and inflammatory diseases.

Keywords: purinergic signaling, Neutrophil, innate immune, Inflammation, purinergic receptor

Received: 15 Jan 2018; Accepted: 13 Feb 2018.

Edited by:

Heiko Mühl, Goethe University Frankfurt, Germany

Reviewed by:

Ben A. Croker, Boston Children's Hospital, United States
Mausita Karmakar, Case Western Reserve University, United States
Ronald Sluyter, University of Wollongong, Australia  

Copyright: © 2018 Wang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
MD, PhD. Xu Wang, Jiangsu University, The Affiliated Hospital, Zhenjiang, China, jsdxwx@126.com
MD, PhD. Deyu Chen, Jiangsu University, The Affiliated Hospital, Zhenjiang, China, cdeyu@hotmail.com