Understanding the cellular origin of the mononuclear phagocyte system sheds light on the myeloid postulate of immune paralysis in sepsis.
- 1UMR8204 Centre d'infection et d'immunité de Lille (CIIL), France
Sepsis, in essence, is a serious clinical condition that can subsequently result in death as a consequence of a systemic inflammatory response syndrome including febrile leukopenia, hypotension and multiple organ failures. To date, such life-threatening organ dysfunction remains one of the leading causes of death in intensive care units, with an increasing incidence rate worldwide and particularly within the rapidly growing senior population. While most of clinical trials are aimed at dampening the overwhelming immune response to infection that spreads through the bloodstream, based on several human immunological investigations it is now widely accepted that susceptibility to nosocomial infections and long-term sepsis mortality involves an immunosuppressive phase that is characterized by a decrease in some subsets of dendritic cells. Only recently have substantial advances been made in terms of the origin of the mononuclear phagocyte system that is now likely to allow for a better understanding of how the paralysis of dendritic cells leads to sepsis-related death. Indeed, the unifying view of each subset of dendritic cells has already improved our understanding of the pivotal pathways that contribute to the shift in commitment of their progenitors that originate from the bone marrow. It is quite plausible that this anomaly in sepsis may occur at the single level of dendritic cell-committed precursors, and elucidating the immunological basis for such a derangement during the ontogeny of each subset of dendritic cells is now of particular importance for restoring an adequate cell fate decision to their vulnerable progenitors. Last but not least, it provides a direct perspective on the development of sophisticated myelopoiesis-based strategies that are currently being considered for the treatment of immunosenescence within different microenvironments, such as the kidney and the spleen.
Keywords: dendritic cell, Monocytes, Ontogeny, Sepsis, Endotoxemia
Received: 22 Sep 2017;
Accepted: 04 Apr 2018.
Edited by:Etienne Meunier, UMR5089 Institut de Pharmacologie et de Biologie Structurale (IPBS), France
Reviewed by:Marc DALOD, Centre national de la recherche scientifique (CNRS), France
Paul Fisch, Universitätsklinikum Freiburg, Germany
Copyright: © 2018 Lasseaux, Chamaillard and Poulin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Dr. Lionel F. Poulin, UMR8204 Centre d'infection et d'immunité de Lille (CIIL), Lille, France, firstname.lastname@example.org